ArticleFrontiers in neuroinformatics2020
Development of a Non-invasive Deep Brain Stimulator With Precise Positioning and Real-Time Monitoring of Bioimpedance.
Article in Frontiers in neuroinformatics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Triangular Wave tACS Improves Working Memory Performance by Enhancing Brain Activity in the Early Stage of Encoding.Neuroscience bulletin · 2025Trial
- Biochemical Pathways of Neuroplasticity in Sport Skill Acquisition: From Neuroscience to Coaching Practice.Brain sciences · 2026Review
- Mapping the Global Trajectory and Key Trends of Temporal Interference Stimulation.Bioengineering (Basel, Switzerland) · 2026Article
- Transcranial Temporal Interference Stimulation: A Brief Review of Architectures, Circuits, and Application Challenges.IEEE open journal of engineering in medicine and biology · 2026Article
- Analysis of biological systems using bioimpedance spectroscopy: a critical review of technological convergence and translational challenges.Frontiers in bioengineering and biotechnology · 2026Review
- Review
- Gamma Transcranial Alternating Current Stimulation Enhances Working Memory Ability in Healthy People: An EEG Microstate Study.Brain sciences · 2025Article
- Pilot study of using transcranial temporal interfering theta-burst stimulation for modulating motor excitability in rat.Journal of neuroengineering and rehabilitation · 2024Article
- Insights from a model based study on optimizing non invasive brain electrical stimulation for Parkinson's disease.Scientific reports · 2024Article
- Temporal interference current stimulation in peripheral nerves is not driven by envelope extraction.Journal of neural engineering · 2023Article
- A novel non-invasive brain stimulation technique: "Temporally interfering electrical stimulation".Frontiers in neuroscience · 2023Review
- Safety Evaluation of Employing Temporal Interference Transcranial Alternating Current Stimulation in Human Studies.Brain sciences · 2022Article
- Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Influence of layered skull modeling on the frequency sensitivity and target accuracy in simulations of transcranial current stimulation.Human brain mapping · 2021Article
- Review of Noninvasive or Minimally Invasive Deep Brain Stimulation.Frontiers in behavioral neuroscience · 2021Review
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Methods by which to achieve non-invasive deep brain stimulation via temporally interfering with electric fields have been proposed, but the precision of the positioning of the stimulation and the reliability and stability of the outputs require improvement. In this study, a temporally interfering electrical stimulator was developed based on a neuromodulation technique using the interference modulation waveform produced by several high-frequency electrical stimuli to treat neurodegenerative diseases. The device and auxiliary software constitute a non-invasive neuromodulation system. The technical problems related to the multichannel high-precision output of the device were solved by an analog phase accumulator and a special driving circuit to reduce crosstalk. The function of measuring bioimpedance in real time was integrated into the stimulator to improve effectiveness. Finite element simulation and phantom measurements were performed to find the functional relations among the target coordinates, current ratio, and electrode position in the simplified model. Then, an appropriate approach was proposed to find electrode configurations for desired target locations in a detailed and realistic mouse model. A mouse validation experiment was carried out under the guidance of a simulation, and the reliability and positioning accuracy of temporally interfering electric stimulators were verified. Stimulator improvement and precision positioning solutions promise opportunities for further studies of temporally interfering electrical stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.