Evidence map›Paper›PMID 33363375›Full record

ArticleNeuropsychiatric disease and treatment2020

Impaired Cognitive Abilities in Siblings of Patients with Temporal Lobe Epilepsy.

Langzi Tan, Yayu Chen, Wenyue Wu, Chaorong Liu, Yujiao Fu, Jialinzi He, Min Zhang, Ge Wang, Kangrun Wang, Hongyu Long and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychiatric disease and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Langzi TanDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Yayu ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Wenyue WuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Chaorong LiuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Yujiao FuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.ORCID 0000-0001-8348-786X
Jialinzi HeDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Min ZhangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Ge WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Kangrun WangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.ORCID 0000-0002-8145-3321
Hongyu LongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Wenbiao XiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Bo XiaoDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Lili LongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePatients with temporal lobe epilepsy (TLE) are at high risk of cognitive impairment. In addition to persistent seizures and antiepileptic drugs (AEDs), genetic factors also play an important role in the progression of cognitive deficits in TLE patients. Defining a cognitive endophenotype for TLE can provide information on the risk of cognitive impairment in patients. This study investigated the cognitive endophenotype of TLE by comparing neuropsychological function between patients with TLE, their unaffected siblings, and healthy control subjects. PATIENTS AND

methodsA total of 46 patients with TLE, 26 siblings, and 33 control subjects were recruited. Cognitive function (ie, general cognition, short- and long-term memory, attention, visuospatial and executive functions, and working memory) was assessed with a battery of neuropsychological tests. Differences between groups were evaluated by analysis of covariance, with age and years of education as covariates. The Kruskal-Wallis test was used to evaluate data that did not satisfy the homogeneity of variance assumption. Pairwise comparisons were adjusted by Bonferroni correction, with a significance threshold of P<0.05.

resultsPatients with TLE showed deficits in the information test (P<0.001), arithmetic test (P=0.003), digit symbol substitution test (P=0.001), block design test (BDT; P=0.005), and backward digit span test (P=0.001) and took a longer time to complete the Hayling test Part A (P=0.011) compared to controls. Left TLE patients tended to have worse executive function test scores than right TLE patients. The siblings of TLE patients showed deficits in the BDT (P=0.006, Bonferroni-corrected) relative to controls.

conclusionPatients with TLE exhibit cognitive impairment. Executive function is worse in patients with left TLE than in those with right TLE. Siblings show impaired visuospatial function relative to controls. Thus, cognitive deficits in TLE patients have a genetic component and are independent of seizures or AED use.

Indexed as

cognitive impairmentendophenotypetemporal lobe epilepsy

Identifiers

PMID33363375
PMCPMC7752648
OpenAlexW3111828632

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.