Evidence map›Paper›PMID 33363370›Full record

ArticleInternational journal of nanomedicine2020

Selenium-Doped Carbon Quantum Dots Efficiently Ameliorate Secondary Spinal Cord Injury via Scavenging Reactive Oxygen Species.

Wenqi Luo, Yiming Wang, Feng Lin, Yixuan Liu, Rui Gu, Wanguo Liu, Chunsheng Xiao

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 93 citations in OpenAlex.

  1. Review
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  6. Research Progress on Biomaterials for Spinal Cord Repair.International journal of nanomedicine · 2025
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  20. Carbon Dots for the Treatment of Inflammatory Diseases: An Appraisal ofOxidative medicine and cellular longevity · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Wenqi LuoDepartment of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People's Republic of China.
Yiming WangDepartment of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People's Republic of China.
Feng LinDepartment of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People's Republic of China.
Yixuan LiuKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
Rui GuDepartment of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People's Republic of China.
Wanguo LiuDepartment of Orthopaedic Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, People's Republic of China.
Chunsheng XiaoKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.ORCID 0000-0001-7936-4146
Union Hospital · CNChinese Academy of Sciences · CNUniversity of Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe excess production of reactive oxygen species (ROS) after traumatic spinal cord injury (TSCI) has been identified as a leading cause of secondary injury, which can significantly exacerbate acute damage in the injured spinal cord. Thus, scavenging of ROS has emerged as an effective route to ameliorate secondary spinal cord injury. PURPOSE: Selenium-doped carbon quantum dots (Se-CQDs) with the ability to scavenge reactive oxygen species were prepared and used for efficiently ameliorating secondary injury in TSCI.

methodsWater-soluble Se-CQDs were easily synthesized via hydrothermal treatment of l-selenocystine. The chemical structure, size, and morphology of the Se-CQDs were characterized in detail. The biocompatibility and protective effects of the Se-CQDs against H

resultsThe obtained Se-CQDs exhibited good biocompatibility and remarkable protective effect against H

conclusionThis study suggests that Se-CQDs can be used as a promising therapeutic platform for ameliorating secondary injury in TSCI.

Indexed as

AnimalsAnti-Inflammatory AgentsAntioxidantsApoptosisAstrocytesCarbonDisease Models, AnimalFemaleMiceMotor ActivityNeurogliaNeuroprotectionNeuroprotective AgentsPC12 CellsQuantum DotsRatsAnti-Inflammatory AgentsAntioxidantsCarbonNeuroprotective AgentsReactive Oxygen SpeciesSeleniumantioxidantcarbon quantum dotsinflammationreactive oxygen speciesspinal cord injury

Identifiers

PMID33363370
PMCPMC7754097
OpenAlexW3111557069

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.