Evidence map›Paper›PMID 33363050›Full record

ArticleFrontiers in cellular and infection microbiology2020

A Metagenome-Wide Association Study of Gut Microbiome in Patients With Multiple Sclerosis Revealed Novel Disease Pathology.

Toshihiro Kishikawa, Kotaro Ogawa, Daisuke Motooka, Akiko Hosokawa, Makoto Kinoshita, Ken Suzuki, Kenichi Yamamoto, Tatsuo Masuda, Yuki Matsumoto, Takuro Nii and 6 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Bibliometric Visualization Analysis of Microbiome-Gut-Brain Axis from 2004 to 2020.Medical science monitor : international medical journal of experimental and clinical research · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Toshihiro KishikawaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Kotaro OgawaDepartment of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
Daisuke MotookaDepartment of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Akiko HosokawaDepartment of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
Makoto KinoshitaDepartment of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
Ken SuzukiDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Kenichi YamamotoDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Tatsuo MasudaDepartment of Obstetrics and Gynecology, Osaka University Graduate School of Medicine, Suita, Japan.
Yuki MatsumotoDepartment of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Takuro NiiDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Yuichi MaedaDepartment of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine, Suita, Japan.
Shota NakamuraDepartment of Infection Metagenomics, Research Institute for Microbial Diseases, Osaka University, Suita, Japan.
Hidenori InoharaDepartment of Otorhinolaryngology-Head and Neck Surgery, Osaka University Graduate School of Medicine, Suita, Japan.
Hideki MochizukiDepartment of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
Tatsusada OkunoDepartment of Neurology, Osaka University Graduate School of Medicine, Suita, Japan.
Yukinori OkadaDepartment of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Osaka University · JPJapan Community Healthcare Organization · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While microbiome plays key roles in the etiology of multiple sclerosis (MS), its mechanism remains elusive. Here, we conducted a comprehensive metagenome-wide association study (MWAS) of the relapsing-remitting MS gut microbiome (

Indexed as

Gastrointestinal MicrobiomeMultiple SclerosisGemellaGenome-Wide Association StudyHumansMetagenomePhylogenydysbiosisgenome-wide association studygut microbiomemetagenome shotgun sequencingmultiple sclerosis

Identifiers

PMID33363050
PMCPMC7759502
OpenAlexW3110651362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.