ArticleWorld journal of gastrointestinal oncology2020
Prognostic impact of at least 12 lymph nodes after neoadjuvant therapy in rectal cancer: A meta-analysis.
Article in World journal of gastrointestinal oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review and meta-analysis of the use of methylene blue to improve the lymph node harvest in rectal cancer surgery.Techniques in coloproctology · 2023Pooled it
- Development and validation of a nomogram to predict overall survival in young non-metastatic rectal cancer patients after curative resection: a population-based analysis.International journal of colorectal disease · 2022Trial
- Prognostic value of lymph node ratio in resectable rectal cancer after preoperative short-course radiotherapy-results from randomized clinical trial.Langenbeck's archives of surgery · 2022Trial
- Carbon nanoparticle suspension could help get a more accurate nodal staging for patient with rectal cancer.Scientific reports · 2021Trial
- Understanding Textbook outcome failure after robotic colorectal cancer surgery: a multicenter domain-specific analysis.Journal of robotic surgery · 2026Observational
- A prospective analysis of lymph node retrieval in colorectal cancer: discrepancies, neoadjuvant impact, and practical implications.Frontiers in medicine · 2025Article
- Feasibility of indocyanine green (ICG) fluorescence inPathology oncology research : POR · 2024Article
- Prognostic significance of lymph node yield on oncologic outcomes according to tumor response after preoperative chemoradiotherapy in rectal cancer patients.Annals of coloproctology · 2023Article
- Predictors and survival outcomes of having less than 12 harvested lymph nodes in proctectomy for rectal cancer.International journal of colorectal disease · 2023Article
- Lymph node harvest as a predictor of survival for colon cancer: A systematic review and meta-analysis.Surgery in practice and science · 2023Review
- A prognostic nomogram for stage II/III rectal cancer patients treated with neoadjuvant chemoradiotherapy followed by surgical resection.BMC surgery · 2022Article
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Authors and funding
7 authors.
Funding
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Abstract
backgroundThe number of dissected lymph nodes (LNs) in rectal cancer after neoadjuvant therapy has a controversial effect on the prognosis.
aimTo investigate the prognostic impact of the number of LN dissected in rectal cancer patients after neoadjuvant therapy.
methodsWe performed a systematic review and searched PubMed, Embase (Ovid), MEDLINE (Ovid), Web of Science, and Cochrane Library from January 1, 2000 until January 1, 2020. Two reviewers examined all the publications independently and extracted the relevant data. Articles were eligible for inclusion if they compared the number of LNs in rectal cancer specimens resected after neoadjuvant treatment (LNs ≥ 12
resultsNine articles were included in the meta-analyses. Statistical analysis revealed a statistically significant difference in OS [hazard ratio (HR) = 0.76, 95% confidence interval (CI): 0.66-0.88,
conclusionAlthough neoadjuvant therapy reduces LN production in rectal cancer, our data indicate that dissecting at least 12 LNs after neoadjuvant therapy may improve the patients' OS, DFS, and DR.
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