ReviewFrontiers in immunology2020
Update of Immunosenescence in Cerebral Small Vessel Disease.
Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Biomarker advancements in cerebral small vessel disease: An overview.Neural regeneration research · 2026Article
- Neuroinflammation and blood-brain barrier dysfunction in cerebral small vessel disease: mechanisms, biomarkers, and therapeutic implications.European journal of medical research · 2026Review
- NK Cell Senescence in Cancer: From Molecular Mechanisms to Therapeutic Opportunities.Aging and disease · 2025Review
- Review of the mechanism of infection induced cerebral small vessel disease.Frontiers in immunology · 2025Review
- Bridging the gap: Exploring the intercurrent relationship between knee osteoarthritis and cerebral small vessel disease.Caspian journal of internal medicine · 2025Review
- The correlation analysis between preoperative cerebral small vessel disease and carotid plaque echo characteristics.Frontiers in neurology · 2025Article
- Age-Related Alterations in Immune Function and Inflammation: Focus on Ischemic Stroke.Aging and disease · 2024Review
- Correlations among lymphocyte count, white matter hyperintensity and brain atrophy in patients with ischemic stroke.Frontiers in aging neuroscience · 2024Article
- A bibliometric analysis of cerebral small vessel disease.Frontiers in aging neuroscience · 2024Article
- Plasma Inflammatory Biomarkers Are Associated With Poststroke Cognitive Impairment: The Nor-COAST Study.Stroke · 2023Observational
- Plasma inflammatory biomarkers in cerebral small vessel disease: A review.CNS neuroscience & therapeutics · 2023Review
- Systemic immune-inflammation index is associated with white matter hyperintensity volume.Scientific reports · 2022Article
- Age-related immune alterations and cerebrovascular inflammation.Molecular psychiatry · 2022Review
- Potential biomarkers of Alzheimer's disease and cerebral small vessel disease.Frontiers in molecular neuroscience · 2022Article
- Cerebral Small Vessel Disease: Neuroimaging Features, Biochemical Markers, Influencing Factors, Pathological Mechanism and Treatment.Frontiers in neurology · 2022Review
- Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors.Frontiers in aging neuroscience · 2021Article
- Dynamic Aging: Channeled Through Microenvironment.Frontiers in physiology · 2021Review
- Association of systemic inflammatory markers with white matter hyperintensities and microstructural injury: an analysis of UK Biobank data.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging of the central nervous system (CNS) is closely associated with chronic sterile low-grade inflammation in older organisms and related immune response. As an amplifier for neuro-inflammaging, immunosenescence remodels and deteriorates immune systems gradually with the passage of time, and finally contributes to severe outcomes like stroke, dementia and neurodegeneration in elderly adults. Cerebral small vessel disease (CSVD), one of the major causes of vascular dementia, has an intensive connection with the inflammatory response and immunosenescence plays a crucial role in the pathology of this disorder. In this review, we discuss the impact of immunosenescence on the development of CSVD and its underlying mechanism. Furthermore, the clinical practice significance of immunosenescence management and the diagnosis and treatment of CSVD will be also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.