Evidence map›Paper›PMID 33362760›Full record

ArticleFrontiers in immunology2020

Neutrophil Inflammatory Response Is Downregulated by Uptake of Superparamagnetic Iron Oxide Nanoparticle Therapeutics.

Gustavo Garcia, Min-Ho Kim, Vasilios Aris Morikis, Scott I Simon

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

  1. Iron Deficiency-More Than Just Anemia: A Literature Review.Journal of community hospital internal medicine perspectives · 2025
    Review
  2. Article
  3. Review
  4. Article
  5. New Concepts on the Pathophysiology of Acute Coronary Syndrome.Reviews in cardiovascular medicine · 2023
    Review
  6. FePharmaceutics · 2023
    Article
  7. Article
  8. Review
  9. Particle uptake driven phagocytosis in macrophages and neutrophils enhances bacterial clearance.Journal of controlled release : official journal of the Controlled Release Society · 2022
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Gustavo GarciaDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States.
Min-Ho KimDepartment of Biological Sciences, Kent State University, Kent, OH, United States.
Vasilios Aris MorikisDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States.
Scott I SimonDepartment of Biomedical Engineering, University of California, Davis, Davis, CA, United States.
University of California, Davis · USKent State University · US

Funding

Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Outside-in Mechanotransduced Inflammatory TargetsR01AI047294 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI SIMON, SCOTT IRWIN · 1999 to 2021
$7.0M
Targeted magnetic nanoparticle hyperthermia for minimally invasive disruption of amyloid beta plaques towards the treatment of Alzheimer's diseaseR01NR015674 · NINR · KENT STATE UNIVERSITY · PI KIM, MIN HO · 2015 to 2019
$2.2M
NHLBI NIH HHS T32 HL086350NIAID NIH HHS R01 AI047294NINR NIH HHS R01 NR015674
6 · The paper itself

Abstract

Superparamagnetic iron oxide nanoparticles (SPION) are employed as diagnostics and therapeutics following intravenous delivery for the treatment of iron deficiency anemia (IDA) in adult patients with chronic kidney failure. Neutrophils are the first defense against blood borne foreign insult and recruit to vascular sites of inflammation

Indexed as

Anemia, Iron-DeficiencyCalcium SignalingCD18 AntigensCell DegranulationCells, CulturedFerrosoferric OxideHumansInflammationInterleukin-8Kidney Failure, ChronicL-SelectinMagnetic Iron Oxide NanoparticlesNeutrophil ActivationNeutrophilsReceptors, Interleukin-8ACD18 AntigensFerrosoferric OxideInterleukin-8L-SelectinReceptors, Interleukin-8Aimmunosupressioninflammationinnate immunityiron oxidemechanosignalingnanoparticleneutrophil degranulationneutrophil recruitment

Identifiers

PMID33362760
PMCPMC7757401
OpenAlexW3111614752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.