ArticleFrontiers in human neuroscience2020
Alteration of Cortical and Subcortical Structures in Children With Profound Sensorineural Hearing Loss.
Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Functional-Structural Coupling: Brain Reorganization in Presbycusis Is Related to Cognitive Impairment.eNeuro · 2026Article
- Cortical Structure Abnormalities in Patients With Noise-Induced Hearing Loss: A Surface-Based Morphometry Study.Brain and behavior · 2025Article
- Accelerated Brain Atrophy, Microstructural Decline and Connectopathy in Age-Related Macular Degeneration.Biomedicines · 2024Article
- Cerebral cortex functional reorganization in preschool children with congenital sensorineural hearing loss: a resting-state fMRI study.Frontiers in neurology · 2024Article
- Altered static and dynamic intrinsic brain activity in unilateral sudden sensorineural hearing loss.Frontiers in neuroscience · 2023Article
- Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness.Children (Basel, Switzerland) · 2022Article
- Cerebral Blood Flow Pattern Changes in Unilateral Sudden Sensorineural Hearing Loss.Frontiers in neuroscience · 2022Article
- Altered Functional Network in Infants With Profound Bilateral Congenital Sensorineural Hearing Loss: A Graph Theory Analysis.Frontiers in neuroscience · 2021Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Profound sensorineural hearing loss (SNHL) is an auditory disability associated with auditory and cognitive dysfunction. Due to distinct pathogenesis, some associated structural and functional changes within the brain have been investigated in previous studies, but whole-brain structural alterations are incompletely understood. We extended the exploration of neuroanatomic differences in whole-brain structure in children with profound SNHL who are primarily users of Chinese sign language (CSL). We employed surface-based morphometry (SBM) and subcortical analyses. T1-weighted magnetic resonance images of 26 children with profound SNHL and 27 age- and sex-matched children with normal hearing were analyzed. Compared with the normal control (NC) group, children with profound SNHL showed diverse structural changes in surface-based and subcortical analyses, including decreased cortical thickness in the left postcentral gyrus, superior parietal lobule, paracentral lobule, precuneus, the right transverse temporal gyri, and the middle temporal gyrus; a noticeable increase in the Local Gyrification Index (LGI) in the left precuneus and superior parietal lobule; and diverse changes in gray-matter volume (GMV) in different brain regions. Surface-based vertex analyses revealed regional contractions in the right thalamus, putamen, pallidum, and the brainstem of children with profound SNHL when compared with those in the NC group. Volumetric analyses showed decreased volumes of the right thalamus and pallidum in children with profound SNHL. Our data suggest that children with profound SNHL are associated with diffuse cerebral dysfunction to cortical and subcortical nuclei, and revealed neuroplastic reorganization in the precuneus, superior parietal lobule, and temporal gyrus. Our study provides robust evidence for changes in connectivity and structure in the brain associated with hearing loss.
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