ArticleFrontiers in neuroscience2020
Morphometric Changes to Corneal Dendritic Cells in Individuals With Mild Cognitive Impairment.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Corneal Immune Cell Alterations and Tau Pathology in a Mouse Model of Alzheimer's Disease.Investigative ophthalmology & visual science · 2026Article
- Review
- Ocular Surface Changes Associated with Neurological Diseases.Medicina (Kaunas, Lithuania) · 2025Review
- Ocular changes as potential biomarkers for early diagnosis of Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Quantifying the Corneal Nerve Whorl Pattern.Translational vision science & technology · 2024Article
- Redefining our vision: an updated guide to the ocular immune system.Nature reviews. Immunology · 2024Review
- Oculomics: A Crusade Against the Four Horsemen of Chronic Disease.Ophthalmology and therapy · 2024Review
- Epithelial Immune Cell Response to Initial Soft Contact Lens Wear in the Human Corneal and Conjunctival Epithelium.Investigative ophthalmology & visual science · 2023Article
- Neuroinflammatory Findings of Corneal Confocal Microscopy in Long COVID-19 Patients, 2 Years after Acute SARS-CoV-2 Infection.Diagnostics (Basel, Switzerland) · 2023Article
- Corneal nerve loss and increased Langerhans cells are associated with disease severity in patients with rheumatoid arthritis.Eye (London, England) · 2023Article
- Potential Ocular Biomarkers for Early Detection of Alzheimer's Disease and Their Roles in Artificial Intelligence Studies.Neurology and therapy · 2023Review
- Redefining the human corneal immune compartment using dynamic intravital imaging.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Corneal nerve loss predicts dementia in patients with mild cognitive impairment.Annals of clinical and translational neurology · 2023Article
- Update on Corneal Confocal Microscopy Imaging.Diagnostics (Basel, Switzerland) · 2022Review
- Corneal Dendritic Cell Dynamics Are Associated with Clinical Factors in Type 1 Diabetes.Journal of clinical medicine · 2022Article
- Small fiber neuropathy for assessment of disease severity in amyotrophic lateral sclerosis: corneal confocal microscopy findings.Orphanet journal of rare diseases · 2022Article
- Defining an Optimal Sample Size for Corneal Epithelial Immune Cell Analysis UsingFrontiers in medicine · 2022Article
- Analysis of Globular Cells in Corneal Nerve Vortex.Frontiers in medicine · 2022Article
- Altered Corneal Epithelial Dendritic Cell Morphology and Phenotype Following Acute Exposure to Hyperosmolar Saline.Investigative ophthalmology & visual science · 2021Article
- Ophthalmic Biomarkers for Alzheimer's Disease: A Review.Frontiers in aging neuroscience · 2021Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThere has been increasing interest in identifying non-invasive, imaging biomarkers for neurodegenerative disorders of the central nervous system (CNS). The aim of this proof-of-concept study was to investigate whether corneal sensory nerve and dendritic cell (DC) parameters, captured using
methodsFifteen participants were recruited from the Australian Imaging Biomarkers and Lifestyle (AIBL) study in Melbourne, VIC, Australia. The cohort consisted of cognitively normal (CN) individuals (
resultsCorneal DC field area and perimeter were greater in individuals with MCI, relative to CN controls, in both the central and inferior whorl regions (
conclusionThis study is the first to report morphological differences in corneal DCs in humans with MCI. These differences were evident in both the central and mid-peripheral cornea, and in the absence of significant nerve abnormalities or a difference in DC density. These findings justify future large-scale studies to assess the utility of corneal IVCM and DC analysis for identifying early stage pathology in neurodegenerative disorders of the CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.