Evidence map›Paper›PMID 33362382›Full record

ArticleWorld journal of gastroenterology2020

Tuberous sclerosis patient with neuroendocrine carcinoma of the esophagogastric junction: A case report.

Natsuki Ishida, Takahiro Miyazu, Satoshi Tamura, Satoshi Suzuki, Shinya Tani, Mihoko Yamade, Moriya Iwaizumi, Satoshi Osawa, Yasushi Hamaya, Kazuya Shinmura and 4 more

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Natsuki IshidaFirst Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Takahiro MiyazuFirst Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Satoshi TamuraFirst Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Satoshi SuzukiDepartment of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Shinya TaniDepartment of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Mihoko YamadeFirst Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Moriya IwaizumiDepartment of Laboratory Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Satoshi OsawaDepartment of Endoscopic and Photodynamic Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Yasushi HamayaFirst Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Kazuya ShinmuraDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Haruhiko SugimuraDepartment of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Katsutoshi MiuraDepartment of Health Science, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Takahisa FurutaCenter for Clinical Research, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan.
Ken SugimotoFirst Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan. sugimken@hama-med.ac.jp.
Hamamatsu University School of Medicine · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTuberous sclerosis complex (TSC) is a rare inherited disease with non-cancerous tumor growths in the skin, brain, kidneys, heart, and lungs. The co-occurrence of neuroendocrine neoplasm (NEN) with TSC is even rarer. There have been few reports on the relationship between TSC and neuroendocrine tumors (NETs), and fewer on the relationship between TSC and neuroendocrine carcinoma (NEC), a subtype of NEN. This is the first reported case of NEC occurring at the esophagogastric junction in a patient with TSC. CASE SUMMARY: A 46-year-old woman visiting our hospital for the treatment of TSC was admitted to the emergency department with tarry stools and dizziness. Computed tomography scans revealed thickness of the gastric cardia, multiple metastatic lesions of the liver, and enlarged lymph nodes near the lesser curvature of the stomach. Esophagogastroduodenoscopy revealed a type 3 tumor located from the esophagogastric junction to the fundus, and the pathological diagnosis by biopsy was NEC. The patient was treated with seven courses of cisplatin + irinotecan, followed by eight courses of ramucirumab + nab-paclitaxel, one course of nivolumab, and two courses of S-1 + oxaliplatin. Twenty-three months after the first treatment, the patient died because of disease progression and deterioration of the general condition.

conclusionThis case of NEC occurring in a patient with TSC indicates a difference in the occurrence of NETs and NECs.

Indexed as

Carcinoma, NeuroendocrineStomach NeoplasmsTuberous SclerosisEsophagogastric JunctionFemaleHumansInfant, NewbornIrinotecanMiddle AgedIrinotecanCase reportChemotherapyEsophagogastric junctionmTOR inhibitorNeuroendocrine carcinomaNeuroendocrine tumorTuberous sclerosis complex

Identifiers

PMID33362382
PMCPMC7723665
OpenAlexW3112988374

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.