SynthesisWorld journal of gastroenterology2020
Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding: A systematic review.
Synthesis in World journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intravenous Ferric Carboxymaltose Versus Oral Ferrous Sulfate Replacement in Anaemia Due to Acute Nonvariceal Gastrointestinal Bleeding (FIERCE): Protocol of a Multicentre Randomised Controlled Trial
Awareness of the Need for the Evaluation of Iron Status Among Hospitalized Patients With Acute Upper Gastrointestinal Bleeding.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Taiwan practical consensus for evaluation and management of small-bowel bleeding.Journal of the Chinese Medical Association : JCMA · 2026Guideline
- Hemoglobinometry at the point of care with activation of a hospital transfusion pathway versus usual care for the early detection of anaemia in primary care: the ANHEMOG randomized controlled trial.BMC primary care · 2026Trial
- [Lower gastrointestinal bleeding secondary to Chronic Nonspecific Ulcerative Colitis: A clinical case].Revista medica del Instituto Mexicano del Seguro Social · 2026Article
- Feasibility of a Noncontact Photoplethysmography-Based Mobile App for Noninvasive Hemoglobin Monitoring: Exploratory Observational Study.JMIR formative research · 2026Observational
- Cobalamin and iron deficiency still presents a challenge in hereditary hemorrhagic telangiectasia.Scientific reports · 2025Article
- Low Rates of Diagnosis and Treatment of Iron Deficiency Anemia After an Acute Severe Gastrointestinal Hemorrhage.Digestive diseases and sciences · 2025Article
- Intravenous Versus Oral Iron After Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.JGH open : an open access journal of gastroenterology and hepatology · 2025Review
- Article
- Article
- Low Rates of Diagnosis and Treatment of Iron Deficiency Anemia After an Acute Severe Gastrointestinal Hemorrhage.Research square · 2024Article
- Clinical management of iron deficiency anemia in Japan: iron prescription patterns, treatment effectiveness, and assessments.International journal of hematology · 2024Article
- Article
- Anaemia in India and Its Prevalence and Multifactorial Aetiology: A Narrative Review.Nutrients · 2024Review
- Role of red blood cells in clinically relevant bleeding tendencies and complications.Journal of thrombosis and haemostasis : JTH · 2023Review
- An unusual cause of iron deficiency anemia in a patient with severe aortic stenosis and heart failure.Journal of cardiology cases · 2023Article
- IntravenousBMJ open · 2023Article
- Strategic Management of Bleeding Small Bowel Gastrointestinal Angiodysplasias (GIADs): A 12 Year Retrospective Review in a Veteran Population and Cost Comparison.Diagnostics (Basel, Switzerland) · 2023Article
- Oral manifestations of iron imbalance.Frontiers in nutrition · 2023Article
- Indications and hemoglobin thresholds for red blood cell transfusion and iron replacement in adults with gastrointestinal bleeding: An algorithm proposed by gastroenterologists and patient blood management experts.Frontiers in medicine · 2022Review
- A Cohort Study to Compare Effects between Ulcer- and Nonulcer-Related Nonvariceal Upper Gastrointestinal Bleeding.Applied bionics and biomechanics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnemia is considered a public health issue and is often caused by iron deficiency. Iron-deficiency anemia (IDA) often originates from blood loss from lesions in the gastrointestinal tract in men and postmenopausal women, and its prevalence among patients with gastrointestinal bleeding has been estimated to be 61%. However, few guidelines regarding the appropriate investigation of patients with IDA due to gastrointestinal bleeding have been published.
aimTo review current evidence and guidelines concerning IDA management in gastrointestinal bleeding patients to develop recommendations for its diagnosis and therapy.
methodsFive gastroenterology experts formed the Digestive Bleeding and Anemia Workgroup and conducted a systematic literature search in PubMed and professional association websites. MEDLINE (
resultsFrom 494 Literature citations found during the initial literature search, 17 original articles, one meta-analysis, and 13 clinical practice guidelines were analyzed. Based on the published evidence and clinical experience, the workgroup developed the following ten recommendations for the management of IDA in patients with gastrointestinal bleeding: (1) Evaluation of hemoglobin and iron status; (2) Laboratory testing; (3) Target treatment population identification; (4) Indications for erythrocyte transfusion; (5) Treatment targets for erythrocyte transfusion; (6) Indications for intravenous iron; (7) Dosages; (8) Monitoring; (9) Indications for intravenous ferric carboxymaltose treatment; and (10) Treatment targets and monitoring of patients. The workgroup also proposed a summary algorithm for the diagnosis and treatment of IDA in patients with acute or chronic gastrointestinal bleeding, which should be implemented during the hospital stay and follow-up visits after patient discharge.
conclusionThese recommendations may serve as a starting point for clinicians to better diagnose and treat IDA in patients with gastrointestinal bleeding, which ultimately may improve health outcomes in these patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.