ArticlePloS one2020
The impact of comorbidities on post-operative complications following colorectal cancer surgery.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Medication Management of Patients With Cancer Undergoing Surgery From Preadmission to Discharge: A Mixed-Methods Systematic Review.Journal of advanced nursing · 2025Pooled it
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- Comparison of outcomes between robot-assisted and laparoscopic colorectal cancer surgery in patients with heart failure: a national readmission database analysis.Surgical endoscopy · 2026Article
- The weight of the most common biological variables in the prediction of adverse events after adult spinal deformity surgery.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Article
- The relationship between the latent profiles of cancer-related fatigue characteristics and exercise adherence in colorectal cancer patients.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Weighing the Risk: The Impact of Obesity on 30-Day Complications After Cosmetic Abdominoplasty-An Observational Cohort Study of 1,778 Cases.Aesthetic plastic surgery · 2026Observational
- General Principles of Risk Mitigation before Colorectal Surgery.Clinics in colon and rectal surgery · 2026Review
- Emergency colorectal cancer in old and very elderly patients: a narrative review.Frontiers in oncology · 2026Review
- Impact of statin therapy on postoperative outcomes following colorectal cancer surgery: A systematic review.World journal of gastrointestinal surgery · 2025Article
- Cost-minimization analysis of postoperative antibiotic use in high horseshoe anal fistula: evidence from a randomized controlled trial in China.Health economics review · 2025Article
- Global benchmarks for minimally invasive right hemicolectomy for cancer.The British journal of surgery · 2025Article
- Postoperative outcomes following prehabilitationWorld journal of gastrointestinal surgery · 2025Article
- Management and risk factors for colonic volvulus: retrospective national cohort study.BJS open · 2025Article
- How aging may impact the failure to rescue after colorectal laparoscopic surgery. Analysis of 1000 patients in a single high-volume center.Updates in surgery · 2025Article
- An assessment of study characteristics, quality and reporting in cancer prehabilitation literature: a scoping review.BMJ open · 2025Article
- Effects of Pre-Operative HbA1c on Outcomes and the Rate of Clinical Improvement Following Anterior Cervical Discectomy and Fusion.Journal of clinical medicine · 2025Article
- Review
- Risk Factors in Elective Colon Surgery for the Elderly: A Retrospective Cohort Analysis From the Swedish Part of the International ERAS Database.World journal of surgery · 2025Article
- Does surgeon or hospital volume influence outcome in dedicated colorectal units?-A Viennese perspective.Wiener klinische Wochenschrift · 2025Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundColorectal cancer surgery is complex and can result in severe post-operative complications. Optimisation of surgical outcomes requires a thorough understanding of the background complexity and comorbid status of patients.
aimThe aim of this study is to determine whether certain pre-existing comorbidities are associated with high grade post-operative complications following colorectal cancer surgery. The study also aims to define the prevalence of demographic, comorbid and surgical features in a population undergoing colorectal cancer resection.
methodA colorectal cancer database at The Prince Charles Hospital was established to capture detailed information on patient background, comorbidities and clinicopathological features. A single-centre retrospective study was undertaken to assess the effect of comorbidities on post-operative outcomes following colorectal cancer resection. Five hundred and thirty-three patients were reviewed between 2010-2018 to assess if specific comorbidities were associated with higher grade post-operative complications. A Clavien-Dindo grade of three or higher was defined as a high grade complication.
resultsFifty-eight percent of all patients had an ASA grade of ASA III or above. The average BMI of patients undergoing resection was 28 ± 6.0. Sixteen percent of all patients experienced a high grade complications. Patients with high grade complications had a higher mean average age compared to patients with low grade or no post-operative complications (74 years vs 70 years, p = 0.01). Univariate analysis revealed patients with atrial fibrillation, COPD, ischaemic heart disease and heart failure had an increased risk of high grade complications. Multivariate analysis revealed pre-existing atrial fibrillation (OR 2.70, 95% CI 1.53-4.89, p <0.01) and COPD (OR 2.02 1.07-3.80, p = 0.029) were independently associated with an increased risk of high grade complications.
conclusionPre-existing atrial fibrillation and COPD are independent risk factors for high grade complications. Targeted perioperative management is necessary to optimise outcomes.
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