Evidence map›Paper›PMID 33362228›Full record

ArticlePloS one2020

Hemodynamic and metabolic recovery in acute myocardial infarction-related cardiogenic shock is more rapid among patients presenting with out-of-hospital cardiac arrest.

Jakob Josiassen, Ole Kristian Lerche Helgestad, Jacob Eifer Møller, Jesper Kjaergaard, Henrik Frederiksen Hoejgaard, Henrik Schmidt, Lisette Okkels Jensen, Lene Holmvang, Hanne Berg Ravn, Christian Hassager

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 44 citations in OpenAlex.

  1. Cardiac index, SvOCritical care (London, England) · 2025
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  2. Trial
  3. Prognostic value of lactate in patients with cardiogenic shock with and without cardiac arrest.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
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  14. Timing and treatment strategies according to SCAI classification in cardiogenic shock.European heart journal supplements : journal of the European Society of Cardiology · 2023
    Article
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  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Jakob JosiassenDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-3984-7781
Ole Kristian Lerche HelgestadDepartment of Cardiology, Odense University Hospital, Odense, Denmark.
Jacob Eifer MøllerDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Jesper KjaergaardDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Henrik Frederiksen HoejgaardDepartment of Cardiothoracic Anesthesia, Odense University Hospital, Odense, Denmark.
Henrik SchmidtDepartment of Cardiothoracic Anesthesia, Odense University Hospital, Odense, Denmark.
Lisette Okkels JensenDepartment of Cardiology, Odense University Hospital, Odense, Denmark.
Lene HolmvangDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Hanne Berg RavnDepartment of Cardiothoracic Anesthesia, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Christian HassagerDepartment of Cardiology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-1199-0981
Odense University Hospital · DKUniversity of Copenhagen · DKCopenhagen University Hospital · DKUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost studies in acute myocardial infarction complicated by cardiogenic shock (AMICS) include patients presenting with and without out-of-hospital cardiac arrest (OHCA). The aim was to compare OHCA and non-OHCA AMICS patients in terms of hemodynamics, management in the intensive care unit (ICU) and outcome.

methodsFrom a cohort corresponding to two thirds of the Danish population, all patients with AMICS admitted from 2010-2017 were individually identified through patient records.

resultsA total of 1716 AMICS patients were identified of which 723 (42%) presented with OHCA. A total of 1532 patients survived to ICU admission. At the time of ICU arrival, there were no differences between OHCA and non-OHCA AMICS patients in variables commonly used in the AMICS definition (mean arterial pressure (MAP) (72mmHg vs 70mmHg, p = 0.12), lactate (4.3mmol/L vs 4.0mmol/L, p = 0.09) and cardiac output (CO) (4.6L/min vs 4.4L/min, p = 0.30)) were observed. However, during the initial days of ICU treatment OHCA patients had a higher MAP despite a lower need for vasoactive drugs, higher CO, SVO2 and lactate clearance compared to non-OHCA patients (p<0.05 for all). In multivariable analysis outcome was similar but cause of death differed significantly with hypoxic brain injury being leading cause in OHCA and cardiac failure in non-OHCA AMICS patients.

conclusionOHCA and non-OHCA AMICS patients initially have comparable metabolic and hemodynamic profiles, but marked differences develop between the groups during the first days of ICU treatment. Thus, pooling of OHCA and non-OHCA patients as one clinical entity in studies should be done with caution.

Indexed as

Acute DiseaseAgedCohort StudiesFemaleHeart-Assist DevicesHemodynamicsHumansIntensive Care UnitsMaleMiddle AgedMyocardial InfarctionOut-of-Hospital Cardiac ArrestRisk FactorsShock, CardiogenicTreatment Outcome

Identifiers

PMID33362228
PMCPMC7757873
OpenAlexW3117983223

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.