SynthesisPloS one2020
Maternal lipid profile and risk of pre-eclampsia in African pregnant women: A systematic review and meta-analysis.
Synthesis in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Highly Atherogenic Lipid Particles are Associated with Preeclampsia After Successful Fertility Treatment for Obese Women who have Unexplained Infertility.Reproductive sciences (Thousand Oaks, Calif.) · 2023Trial
- Role of second-trimester hematological and biochemical indicators in predicting preeclampsia: a retrospective study.BMC pregnancy and childbirth · 2026Article
- Exploring cardiometabolic markers in adverse pregnancy outcomes: insights from the GROWell study.Research square · 2026Article
- Pregestational Cardiometabolic Biomarkers and Future Hypertensive Disorders of Pregnancy.JAMA network open · 2026Article
- Population-based reference intervals for lipid function tests in pregnant and non-pregnant women in Nairobi City, Kenya.Atherosclerosis plus · 2026Article
- The association between early pregnancy maternal lipid indicators with gestational diabetes mellitus and pre-eclampsia.Journal of lipid research · 2025Article
- Machine learning-based management of hypertensive disorders in pregnancy: analysis of differences in key risk factors between gestational hypertension and pre-eclampsia and construction of a pre-eclampsia prediction model.European journal of medical research · 2025Article
- Differences in metabolic adaptations during mid and late pregnancy: a comparative cohort study between Rwanda and Germany.Journal of global health · 2025Article
- Impact of Maternal Metabolic Status on Human Milk Oligosaccharide Composition: A Population-Based Cross-Sectional Study in Central South China.Nutrients · 2025Observational
- Serum Neuropeptide FFR2 is increased in pregnant women with pre-eclampsia and associated with pregnancy outcomes.Pakistan journal of medical sciences · 2025Article
- Lipoprotein(a) throughout life in women.American journal of preventive cardiology · 2024Review
- Prenatal Human Milk Oligosaccharides (HMOs) in the Context of BMI, Gestational Weight Gain, and Lipid Profile-An Association Study in Pregnant Women with Overweight or Obesity.Molecular nutrition & food research · 2024Article
- Evaluation of dyslipidemia in preeclamptic pregnant women and determination of the predictive value of the hemato-lipid profile: A prospective, cross-sectional, case-control study.Turkish journal of obstetrics and gynecology · 2022Article
- Comprehensive fatty acid fractionation profilling in preeclampsia: a case control study with multivariable analysis.BMC pregnancy and childbirth · 2022Article
- Values of First and Early Third Trimesters Serum Lipid Profile in the Prediction of Preeclampsia: A Cohort Study : Preeclampsia and Lipid Profiles.Galen medical journal · 2022Article
- Maternal serum lipids in some women with pre-eclampsia in Yaoundé.The Pan African medical journal · 2021Article
- Hyperlipidemia and risk for preclampsia.Journal of clinical lipidologyReview
- Maternal Lipid Profile as Predictor for Mother and Fetus Outcome-an Artificial Neural Network Approach.Current health sciences journalArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSome studies have reported the association between maternal serum lipid profile abnormalities and pre-eclampsia. However, many studies have reported controversial results. Hence, this systematic review and meta-analysis was planned to generate summarized evidence on the association between maternal serum lipid profiles and pre-eclampsia in African women.
methodsFour electronic databases such as; PubMed, Hinari, Google Scholar, and African Journals Online were searched for studies published in English. Joanna Briggs Institute Meta-Analysis of Statistics Assessment and Review Instrument and Newcastle-Ottawa Scale were used for data extraction and quality assessment of the included studies. The meta- regression analysis was performed by Stata 14 software. The standardized mean difference (SMD) values of lipid profiles were computed to assess their association with pre-eclampsia at 95% CI.
resultsIn this review a total of 15 observational studies were included. The mean values of triglyceride (TG), total cholesterol (TC), low density lipoprotein- cholesterol (LDL-c) and very low density lipoprotein- cholesterol (VLDL-c) were significantly higher in pre-eclamptic women as compared with normotensive pregnant women (TG = 229.61±88.27 and 147.00 ± 40.47, TC = 221.46 ± 45.90 and 189.67 ± 39.18, LDL = 133.92 ± 38.77 and 112.41 ± 36.08, VLDL = 41.44 ± 19.68 and 26.64 ± 7.87), respectively. The serum high density lipoprotein cholesterol (HDL-c) level was lower, but it is not statistically significant (HDL-c = 51.02 ± 16.01 and 61.80 ± 25.63) in pre-eclamptic women as compared with controls. The pooled standardized mean difference (SMD) of TG, TC, LDL-C and VLDL-C were significantly increased in pre-eclamptic women as compared with normotensive pregnant women with the SMD of (TG = 1.65 (1.10, 2.21), TC = 0.84 (0.40, 1.29), LDL-C = 0.95 (0.46, 1.45) and VLDL-C = 1.27 (0.72, 1.81)) at 95% CI, respectively, but the pooled SMD of HDL-cholesterol was decreased in pre-eclamptic women as compared with normotensive pregnant women (SMD = -0.91 (95% CI: -1.43, -0.39).
conclusionsIn this review, the maternal serum levels of TG, TC, LDL-c and VLDL-c were significantly associated with the risk of preeclampsia. However, HDL- cholesterol was not significantly associated but it was lower in pre-eclamptic women. Further, large scale prospective studies should verify these outcomes and it is recommended that lipid profiles should be included as a routine diagnostic test for pre-eclamptic women.
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