Evidence map›Paper›PMID 33361818›Full record

ArticleNature2021

IspH inhibitors kill Gram-negative bacteria and mobilize immune clearance.

Kumar Sachin Singh, Rishabh Sharma, Poli Adi Narayana Reddy, Prashanthi Vonteddu, Madeline Good, Anjana Sundarrajan, Hyeree Choi, Kar Muthumani, Andrew Kossenkov, Aaron R Goldman and 8 more

RetractedOpen access · greenAbstract readRetracted Publication
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
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  6. Article
  7. Article
  8. Review
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  10. Review
  11. Review
  12. Unconventional T cells and kidney disease.Nature reviews. Nephrology · 2021
    Review
  13. Article
  14. Article
  15. Plant Natural Flavonoids Against Multidrug Resistant Pathogens.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021
    Article
  16. Review
  17. Article
  18. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Kumar Sachin SinghVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.
Rishabh SharmaVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.
Poli Adi Narayana ReddyProgram in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA.
Prashanthi VontedduVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.
Madeline GoodProgram in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA.
Anjana SundarrajanVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.
Hyeree ChoiVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.
Kar MuthumaniVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-6807-2065
Andrew KossenkovBioinformatics Facility, The Wistar Institute, Philadelphia, PA, USA.
Aaron R GoldmanProteomics and Metabolomics Facility, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0001-7605-9592
Hsin-Yao TangProteomics and Metabolomics Facility, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-1838-018X
Maxim TotrovMolsoft, San Diego, CA, USA.
Joel CasselMolecular Screening and Protein Expression Facility, The Wistar Institute, Philadelphia, PA, USA.
Maureen E MurphyProgram in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA.
Rajasekharan SomasundaramProgram in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA.
Meenhard HerlynProgram in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-0839-0739
Joseph M SalvinoProgram in Molecular and Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA, USA. jsalvino@wistar.org.ORCID http://orcid.org/0000-0002-2184-5980
Farokh DotiwalaVaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA. fdotiwala@wistar.org.ORCID http://orcid.org/0000-0002-7387-2219
The Wistar Institute · USMolsoft (United States) · US

Funding

Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9M
Purchase of a Q Exactive HF mass spectrometer system for metabolomicsS10OD023586 · OD · WISTAR INSTITUTE · PI SPEICHER, DAVID W. · 2017 to 2017
$600k
NCI NIH HHS P30 CA010815NIH HHS S10 OD023586
6 · The paper itself

Abstract

Isoprenoids are vital for all organisms, in which they maintain membrane stability and support core functions such as respiration

Indexed as

Drug DesignAnimalsDrug Resistance, MicrobialDrug Resistance, MultipleEnzyme InhibitorsEscherichia coli ProteinsFemaleGram-Negative BacteriaHalf-LifeHumansLeukocytes, MononuclearLymphocyte ActivationMaleMiceMice, Inbred BALB CMice, Inbred C57BLEnzyme InhibitorsEscherichia coli ProteinsispH protein, E coliOxidoreductasesProdrugs

Identifiers

PMID33361818
PMCPMC8776033
OpenAlexW3115104186

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.