ArticleNature2021
Chromothripsis drives the evolution of gene amplification in cancer.
Erratum issuedOpen access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 313 papers, 3 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
313citing papers in PubMed, 3 pooled it
18.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
313 citing papers in PubMed, 3 syntheses or guidelines pooled it, 458 citations in OpenAlex.
- Preclinical Anticipation of On- and Off-Target Resistance Mechanisms to Anti-Cancer Drugs: A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Characterization, biogenesis model, and current bioinformatics of human extrachromosomal circular DNA.Frontiers in genetics · 2024Pooled it
- Protective Effects of Micronutrient Supplements, Phytochemicals and Phytochemical-Rich Beverages and Foods Against DNA Damage in Humans: A Systematic Review of Randomized Controlled Trials and Prospective Studies.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- A system-level metastable model of cancer evolution: integrating replication stress, cell cycle deregulation and chromosomal instability.Annals of medicine · 2026Review
- AmpliconSuite: an end-to-end workflow for analyzing focal amplifications in cancer genomes.Nature methods · 2026Article
- A Living Multi-Omics PDX Biobank of High-Risk Sarcomas Reveals ecDNA-Driven Oncogene Amplification in Osteosarcoma and Enables Preclinical Precision Oncology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Circular DNA exposes a weakness in cancer cells.Nature · 2026Article
- Article
- Unraveling the lexicon of complex mutational phenomena in human cancers.Nature cancer · 2026Review
- Clustered structural variant hotspots enable oncogenic addiction and plasticity in osteosarcoma.bioRxiv : the preprint server for biology · 2026Article
- Chromosomal instability in cancer: sources, consequences and new therapeutic opportunities.Signal transduction and targeted therapy · 2026Review
- Extrachromosomal DNA as a platform for epigenetic reprogramming in cancer.Molecular cancer · 2026Review
- The shared evolutionary capacities of plasmids and extrachromosomal DNA.Nature reviews. Genetics · 2026Review
- Extrachromosomal DNA in urothelial carcinoma: mechanisms and clinical applications.Nature reviews. Urology · 2026Review
- Genomic landscape and tumor immune microenvironment of osteosarcoma: Bridging mechanistic insights to precision therapeutics.Bone reports · 2026Review
- Immune pathway activation in gastric cancers with LINE-1 retrotransposon overexpression and homologous recombination deficiency.Experimental & molecular medicine · 2026Article
- Origins and consequences of oncogenic 3D chromatin remodelling.Nature reviews. Cancer · 2026Review
- Phase separation of ecDNA condensates establishes in-trans contact domains that boost selective MYC regulatory interactions.Nature communications · 2026Article
- Examining the role of extrachromosomal DNA in lung cancer.Journal of the National Cancer Institute · 2026Article
- Charting intratumor heterogeneity from bench to bedside.Nature cancer · 2026Review
253 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
15 authors at 5 institutions in 2 countries.
Ofer ShoshaniLudwig Cancer Research, University of California at San Diego, La Jolla, CA, USA.
Simon F BrunnerWellcome Sanger Institute, Hinxton, UK.
Rona YaegerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Peter LyLudwig Cancer Research, University of California at San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0001-8946-7069
Yael Nechemia-ArbelyLudwig Cancer Research, University of California at San Diego, La Jolla, CA, USA.
Dong Hyun KimLudwig Cancer Research, University of California at San Diego, La Jolla, CA, USA.
Rongxin FangLudwig Cancer Research, University of California at San Diego, La Jolla, CA, USA.
Guillaume A CastillonNational Center for Microscopy and Imaging Research (NCMIR), University of California at San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0657-1683
Miao YuLudwig Cancer Research, University of California at San Diego, La Jolla, CA, USA.
Julia S Z LiLudwig Cancer Research, University of California at San Diego, La Jolla, CA, USA.
Ying SunDepartment of Pediatrics, University of California at San Diego, La Jolla, CA, USA.
Mark H EllismanNational Center for Microscopy and Imaging Research (NCMIR), University of California at San Diego, La Jolla, CA, USA.
Bing RenLudwig Cancer Research, University of California at San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0002-5435-1127
Peter J CampbellWellcome Sanger Institute, Hinxton, UK. pc8@sanger.ac.uk.ORCID http://orcid.org/0000-0002-3921-0510
Don W ClevelandLudwig Cancer Research, University of California at San Diego, La Jolla, CA, USA. dcleveland@health.ucsd.edu.ORCID http://orcid.org/0000-0002-1934-3682
University of California San Diego · USMemorial Sloan Kettering Cancer Center · USUniversity of Cambridge · GBUniversity of Pittsburgh · USWellcome Sanger Institute · GB
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4MIVEM and Image Analysis ResourceP41GM103412 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2012 to 2019
$17.9MMechanisms of chromosome segregation, aneuploidy, and tumorigenesisR35GM122476 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Don W Cleveland · 2017 to 2026
$9.0MPredoctoral and Postdoctoral Training in Cancer Cell BiologyT32CA067754 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JEAN Y.J. WANG · 1995 to 2026
$6.5MThe National Center for Microscopy and Imaging Research, a Community-wide Scientific ResourceR24GM137200 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2020 to 2022
$3.0MFEI TITAN HALO 300kV INTERMEDIATE VOLTAGE ELECTRON MICROSCOPES10OD021784 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2017 to 2017
$1.9MCell Division Errors as a Mechanism Driving Massive Genomic RearrangementsK99CA218871 · NCI · LUDWIG INSTITUTE FOR CANCER RES LTD · PI LY, PETER · 2017 to 2018
$236kNCI NIH HHS K99 CA218871NCI NIH HHS P30 CA008748NCI NIH HHS T32 CA067754NIGMS NIH HHS P41 GM103412NIGMS NIH HHS R24 GM137200NIGMS NIH HHS R35 GM122476NIH HHS S10 OD021784Swiss National Science Foundation 171753Wellcome Trust 088340
Abstract
Focal chromosomal amplification contributes to the initiation of cancer by mediating overexpression of oncogenes
Indexed as
ChromothripsisEvolution, MolecularDNA-Activated Protein KinaseDNA, CircularDNA DamageDNA End-Joining RepairDNA, NeoplasmDrug Resistance, NeoplasmGene AmplificationHEK293 CellsHeLa CellsHumansMicronuclei, Chromosome-DefectiveNeoplasmsOncogenesPoly(ADP-ribose) PolymerasesDNA-Activated Protein KinaseDNA, CircularDNA, NeoplasmPoly(ADP-ribose) PolymerasesPRKDC protein, human
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.