ArticleJournal of Parkinson's disease2021
Slow Wave Sleep and EEG Delta Spectral Power are Associated with Cognitive Function in Parkinson's Disease.
Article in Journal of Parkinson's disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- Enhancing sleep slow waves with auditory stimulation in people with Parkinson's disease: a randomized proof-of-concept trial.Scientific reports · 2026Trial
- Closed-loop modulation of sleep in children undergoing intracranial recordings.Cell reports. Medicine · 2026Trial
- Intranasal Dexmedetomidine for the Management of Preoperative Anxiety-Related Insomnia: A Randomized, Three-Blinded, Clinical Trial Compared with Lorazepam and Placebo.Drug design, development and therapy · 2024Trial
- Article
- Home-based deep sleep modulation in Parkinson's disease: extension study on long-term feasibility and sleep-related outcomes.NPJ Parkinson's disease · 2026Article
- Hypnogram-Driven Automatic Sleep Staging and a Quality-Index Assessment Through a Two-Stage LSTM-DNN Ensemble Learning Approach Using Multi-Biosignal Features for Sleep Disorder Detection.Sensors (Basel, Switzerland) · 2026Article
- Refining the Parkinson's Disease Risk Estimator for Decline In Cognition Tool (PREDICT).Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology · 2026Article
- Effects of Hearing Intervention on Cognitive Function in Patients with Presbycusis: A Systematic Review and Meta-Analysis.Audiology research · 2026Review
- Sleep firing rate homeostasis is disrupted in mild parkinsonism.NPJ Parkinson's disease · 2026Article
- Nocturnal heart rate variability in Parkinson's disease: associations with autonomic dysfunction, cognitive function, and mood symptoms.Clinical parkinsonism & related disorders · 2026Article
- SLEEP AND NEURODEGENERATION: EXAMINING POTENTIAL PHYSIOLOGICAL MECHANISMS.Current sleep medicine reports · 2025Article
- The Effects of Multimodal Exercise on Sleep Quality and Architecture, Motor Function, Cognition, Fatigue, and Systemic Inflammation in Corticobasal Syndrome: A Case Report.Physical therapy · 2025Article
- Impaired glymphatic function assessed by DTI-ALPS in drug-naïve Parkinson's disease and its association with motor and non-motor symptoms.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Lack variation of low slow-wave activity over time in the frontal region in NREM sleep may be associated with dyskinesia in Parkinson's disease.CNS neuroscience & therapeutics · 2024Article
- Diffusion Tensor Imaging-Along the Perivascular-Space Index Is Associated with Disease Progression in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2024Article
- Circadian Interventions in Preclinical Models of Huntington's Disease: A Narrative Review.Biomedicines · 2024Review
- Slow-wave sleep dysfunction in mild parkinsonism is associated with excessive beta and reduced delta oscillations in motor cortex.Frontiers in neuroscience · 2024Article
- Brain metabolites are associated with sleep architecture and cognitive functioning in older adults.Brain communications · 2024Article
- Original research: initial development of a pragmatic tool to estimate cognitive decline risk focusing on potentially modifiable factors in Parkinson's disease.Frontiers in neuroscience · 2023Article
- Quantitative sleep electroencephalogram and cognitive performance in Parkinson's disease with and without rapid eye movement sleep behavior disorder.Frontiers in neurology · 2023Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundCognitive and sleep dysfunction are common non-motor symptoms in Parkinson's disease (PD).
objectiveDetermine the relationship between slow wave sleep (SWS) and cognitive performance in PD.
methodsThirty-two PD participants were evaluated with polysomnography and a comprehensive level II neurocognitive battery, as defined by the Movement Disorders Society Task Force for diagnosis of PD-mild cognitive impairment. Raw scores for each test were transformed into z-scores using normative data. Z-scores were averaged to obtain domain scores, and domain scores were averaged to determine the Composite Cognitive Score (CCS), the primary outcome. Participants were grouped by percent of SWS into High SWS and Low SWS groups and compared on CCS and other outcomes using 2-sided t-tests or Mann-Whitney U. Correlations of cognitive outcomes with sleep architecture and EEG spectral power were performed.
resultsParticipants in the High SWS group demonstrated better global cognitive function (CCS) (p = 0.01, effect size: r = 0.45). In exploratory analyses, the High SWS group showed better performance in domains of executive function (effect size: Cohen's d = 1.05), language (d = 0.95), and processing speed (d = 1.12). Percentage of SWS was correlated with global cognition and executive function, language, and processing speed. Frontal EEG delta power during N3 was correlated with the CCS and executive function. Cognition was not correlated with subjective sleep quality.
conclusionIncreased SWS and higher delta spectral power are associated with better cognitive performance in PD. This demonstrates the significant relationship between sleep and cognitive function and suggests that interventions to improve sleep might improve cognition in individuals with PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.