Evidence map›Paper›PMID 33361529›Full record

ArticleAging2020

L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis.

Yassine Ouhaddi, Mehdi Najar, Frédéric Paré, Bertrand Lussier, Yoshihiro Urade, Mohamed Benderdour, Jean-Pierre Pelletier, Johanne Martel-Pelletier, Hassan Fahmi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. Article
  6. Article
  7. Lipocalin-Type Prostaglandin DPharmaceutical research · 2022
    Review
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yassine OuhaddiOsteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), and Department of Medicine, University of Montreal, Montreal, QC H2X 0A9, Canada.
Mehdi NajarOsteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), and Department of Medicine, University of Montreal, Montreal, QC H2X 0A9, Canada.
Frédéric ParéOsteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), and Department of Medicine, University of Montreal, Montreal, QC H2X 0A9, Canada.
Bertrand LussierFaculty of Veterinary Medicine, Clinical Science, University of Montreal, Saint-Hyacinthe, QC, J2S 2M2, Canada.
Yoshihiro UradeIsotope Science Center, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Mohamed BenderdourResearch Centre, Sacré-Coeur Hospital, University of Montreal, Montreal, QC H4J 1C5, Canada.
Jean-Pierre PelletierOsteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), and Department of Medicine, University of Montreal, Montreal, QC H2X 0A9, Canada.
Johanne Martel-PelletierOsteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), and Department of Medicine, University of Montreal, Montreal, QC H2X 0A9, Canada.
Hassan FahmiOsteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), and Department of Medicine, University of Montreal, Montreal, QC H2X 0A9, Canada.
Université de Montréal · CAThe University of Tokyo · JP

Funding

CIHR MOP-130293CIHR PJD 169675
6 · The paper itself

Abstract

Osteoarthritis (OA) is the most common musculoskeletal disorder among the elderly. It is characterized by progressive cartilage degradation, synovial inflammation, subchondral bone remodeling and pain. Lipocalin prostaglandin D synthase (L-PGDS) is responsible for the biosynthesis of PGD

Indexed as

ADAMTS5 ProteinAggrecansAgingAnimalsBehavior, AnimalCartilage, ArticularCell CountCollagen Type IIFemurImmunohistochemistryIntramolecular OxidoreductasesLipocalinsLocomotionMatrix Metalloproteinase 13MiceMice, KnockoutADAMTS5 ProteinAdamts5 protein, mouseAggrecansCollagen Type IIIntramolecular OxidoreductasesLipocalinsMatrix Metalloproteinase 13Mmp13 protein, mouseProstaglandin D2prostaglandin R2 D-isomeraseagingcartilageL-PGDSosteoarthritisPGD2

Identifiers

PMID33361529
PMCPMC7803483
OpenAlexW3115162180

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.