Evidence map›Paper›PMID 33361302›Full record

ArticleAntimicrobial agents and chemotherapy2021

Multiple Single-Nucleotide Polymorphism Detection for Antimalarial Pyrimethamine Resistance via Allele-Specific PCR Coupled with Gold Nanoparticle-Based Lateral Flow Biosensor.

Tingting Jiang, Yan Huang, Weijia Cheng, Yifei Sun, Wei Wei, Kai Wu, Chen Shen, Xiaolong Fu, Haifeng Dong, Jian Li

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
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  3. Article
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  8. Cerebral malaria induced byFrontiers in cellular and infection microbiology · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Tingting Jiang *Department of Human Parasitology, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China.
Yan Huang *Beijing Key Laboratory for Bioengineering and Sensing Technology, Research Centre for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science & Technology, Beijing, China.
Weijia ChengDepartment of Human Parasitology, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China.
Yifei SunDepartment of Human Parasitology, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China.
Wei WeiBeijing Key Laboratory for Bioengineering and Sensing Technology, Research Centre for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science & Technology, Beijing, China.
Kai WuDepartment of Schistosomiasis and Endemic Diseases, Wuhan City Center for Disease Prevention and Control, Wuhan, China.
Chen ShenDepartment of Human Parasitology, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China.
Xiaolong FuDepartment of Human Parasitology, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China.
Haifeng DongBeijing Key Laboratory for Bioengineering and Sensing Technology, Research Centre for Bioengineering and Sensing Technology, School of Chemistry and Biological Engineering, University of Science & Technology, Beijing, China hfdong@ustb.edu.cn yxlijian@163.com.
Jian LiDepartment of Human Parasitology, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China hfdong@ustb.edu.cn yxlijian@163.com.ORCID 0000-0001-9434-7803
Hubei University of Medicine · CNUniversity of Science and Technology Beijing · CNWuhan Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Molecular genotyping holds tremendous potential to detect antimalarial drug resistance (ADR) related to single nucleotide polymorphisms (SNPs). However, it relies on the use of complicated procedures and expensive instruments. Thus, rapid point-of-care testing (POCT) molecular tools are urgently needed for field survey and clinical use. Herein, a POCT platform consisting of multiple-allele-specific PCR (AS-PCR) and a gold nanoparticle (AuNP)-based lateral flow biosensor was designed and developed for SNP detection of the

Indexed as

AntimalarialsBiosensing TechniquesMalaria, FalciparumMetal NanoparticlesAllelesDNA PrimersDrug ResistanceGoldHumansPlasmodium falciparumPolymerase Chain ReactionPyrimethamineSulfadoxineTetrahydrofolate DehydrogenaseAntimalarialsDNA PrimersGoldPyrimethamineSulfadoxineTetrahydrofolate Dehydrogenaseallele-specific PCRantimalarial drug resistancelateral flow biosensorpoint-of-care testing (POCT)single nucleotide polymorphisms (SNPs)

Identifiers

PMID33361302
PMCPMC8092547
OpenAlexW3115838321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.