Evidence map›Paper›PMID 33361301›Full record

ArticleAntimicrobial agents and chemotherapy2021

Metabolites Potentiate Nitrofurans in Nongrowing Escherichia coli.

Sandra J Aedo, Juechun Tang, Mark P Brynildsen

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Metabolism-Based Biomarkers for Rapid Phenotypic Antibiotic Susceptibility Testing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Fluoroquinolone Persistence inMicroorganisms · 2022
    Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sandra J AedoDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, USA.
Juechun TangDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, USA.
Mark P BrynildsenDepartment of Chemical and Biological Engineering, Princeton University, Princeton, New Jersey, USA mbrynild@princeton.edu.ORCID 0000-0001-5707-8894
Princeton University · US

Funding

Examining fluoroquinolone-induced DNA damage in persisters and its contributions to antibiotic resistance.R01AI130293 · NIAID · PRINCETON UNIVERSITY · PI BRYNILDSEN, MARK P · 2017 to 2021
$2.0M
NIAID NIH HHS R01 AI130293
6 · The paper itself

Abstract

Nitrofurantoin (NIT) is a broad-spectrum bactericidal antibiotic used in the treatment of urinary tract infections. It is a prodrug that once activated by nitroreductases goes on to inhibit bacterial DNA, RNA, cell wall, and protein synthesis. Previous work has suggested that NIT retains considerable activity against nongrowing bacteria. Here, we have found that

Indexed as

Escherichia coli InfectionsNitrofuransUrinary Tract InfectionsUropathogenic Escherichia coliHumansNitrofurantoinNitrofuransNitrofurantoinEscherichia colinitrofurantoinurinary tract infection

Identifiers

PMID33361301
PMCPMC8092534
OpenAlexW3114217364

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.