Evidence map›Paper›PMID 33361300›Full record

ArticleAntimicrobial agents and chemotherapy2021

Tetrahydrophthalazinone Inhibitor of Phosphodiesterase with

Julianna Siciliano de Araújo, Raiza Brandão Peres, Patrícia Bernardino da Silva, Marcos Meuser Batista, Geert Jan Sterk, Louis Maes, Guy Caljon, Rob Leurs, Harry P de Koning, Titilola D Kalejaiye and 1 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Julianna Siciliano de AraújoLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Raiza Brandão PeresLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Patrícia Bernardino da SilvaLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Marcos Meuser BatistaLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Geert Jan SterkDivision of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Louis MaesLaboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium.
Guy CaljonLaboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium.ORCID 0000-0002-4870-3202
Rob LeursDivision of Medicinal Chemistry, Faculty of Sciences, Amsterdam Institute for Molecules, Medicines and Systems (AIMMS), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Harry P de KoningInstitute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Titilola D KalejaiyeInstitute of Infection, Immunity & Inflammation, College of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Maria de Nazaré Correia SoeiroLaboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil soeiro@ioc.fiocruz.br.ORCID 0000-0003-0078-6106
Fundação Oswaldo Cruz · BRUniversity of Antwerp · BEUniversity of Glasgow · GBVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The phosphodiesterase inhibitor tetrahydrophthalazinone NPD-008 was explored by phenotypic

Indexed as

Antiprotozoal AgentsChagas DiseaseLeishmania mexicanaTrypanosoma cruziHumansPhosphoric Diester HydrolasesAntiprotozoal AgentsPhosphoric Diester HydrolasescAMPin vitro activityL. amazonensisL. infantumphosphodiesterase inhibitorT. cruzi

Identifiers

PMID33361300
PMCPMC8092546
OpenAlexW3115689494

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.