Evidence map›Paper›PMID 33361295›Full record

ArticleAntimicrobial agents and chemotherapy2021

Effects of Regulatory Network Organization and Environment on PmrD Connector Activity and Polymyxin Resistance in

Annie I Chen, Francisco Javier Albicoro, Jun Zhu, Mark Goulian

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Analysis of stress-induced small proteins inbioRxiv : the preprint server for biology · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. How the PhoP/PhoQ System Controls Virulence and MgMicrobiology and molecular biology reviews : MMBR · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Annie I ChenCell and Molecular Biology Graduate Group, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-2438-0891
Francisco Javier AlbicoroDepartment of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Jun ZhuDepartment of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-9182-5224
Mark GoulianDepartment of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA goulian@sas.upenn.edu.ORCID 0000-0003-0076-023X
University of Pennsylvania · US

Funding

Regulation of Bacterial Two-Component Signaling by Small Membrane ProteinsR01GM080279 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D · 2007 to 2020
$3.7M
ROS responses during Vibrio cholerae infectionR01AI120489 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ZHU, JUN · 2016 to 2020
$2.4M
E. coli niche expansion and adaptation in the dysbiotic intestineR21AI125814 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI GOULIAN, MARK D · 2016 to 2017
$443k
NIAID NIH HHS R01 AI120489NIAID NIH HHS R21 AI125814NIGMS NIH HHS R01 GM080279
6 · The paper itself

Abstract

Polymyxins are a class of cyclic peptides with antimicrobial activity against Gram-negative bacteria. In

Indexed as

Klebsiella pneumoniaePolymyxinsBacterial ProteinsEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialTranscription FactorsBacterial ProteinsEscherichia coli ProteinspmrA protein, BacteriaPmrB protein, bacteriaPmrD protein, E coliPolymyxinsTranscription FactorsconnectorMgrBnatural variationPmrDpolymyxin resistancetwo-component systems

Identifiers

PMID33361295
PMCPMC8092550
OpenAlexW3115358054

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.