Evidence map›Paper›PMID 33361207›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2021

A Critical Role for Na

Ananth K Kammala, Meesum Syed, Canchai Yang, Christopher J Occhiuto, Hariharan Subramanian

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Impact ofJournal of inflammation research · 2025
    Article
  3. Review
  4. Article
  5. NaJournal of immunology (Baltimore, Md. : 1950) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ananth K KammalaDepartment of Physiology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0001-5300-2083
Meesum SyedDepartment of Physiology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0002-2622-9722
Canchai YangDepartment of Physiology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0002-0125-9298
Christopher J OcchiutoDepartment of Physiology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0002-2218-4504
Hariharan SubramanianDepartment of Physiology, Michigan State University, East Lansing, MI 48824 subram46@msu.edu.
Michigan State University · US

Funding

A novel role for the adapter molecule NHERF1 in regulating asthma and allergic reR00HL121073 · NHLBI · MICHIGAN STATE UNIVERSITY · PI SUBRAMANIAN, HARIHARAN · 2016 to 2018
$734k
NHLBI NIH HHS R00 HL121073
6 · The paper itself

Abstract

Mast cells are tissue-resident immune cells that play pivotal roles in initiating and amplifying allergic/anaphylactic reactions in humans. Their activation occurs via multiple mechanisms, which include cross-linking of the IgE-bound, high-affinity IgE receptors (FcεRI) by allergens or Ags and the binding of anaphylatoxins such as C3a to its receptor, C3aR. We have previously demonstrated that the Na

Indexed as

AnimalsCalcium SignalingCell DegranulationCells, CulturedHypersensitivityImmunoglobulin EImmunomodulationMast CellsMiceMice, Inbred C57BLMice, KnockoutMicroRNAsPassive Cutaneous AnaphylaxisPhosphoproteinsReceptors, IgESodium-Hydrogen ExchangersImmunoglobulin EMicroRNAsMirn155 microRNA, mousePhosphoproteinsReceptors, IgEsodium-hydrogen exchanger regulatory factorSodium-Hydrogen Exchangers

Identifiers

PMID33361207
PMCPMC7855521
OpenAlexW3116067203

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.