Evidence map›Paper›PMID 33361193›Full record

ArticleJournal of bacteriology2020

The conserved translation factor LepA is required for optimal synthesis of a porin family in

Skye R S Fishbein, Francesca G Tomasi, Ian D Wolf, Charles L Dulberger, Albert Wang, Hasmik Keshishian, Luke Wallace, Steven A Carr, Thomas R Ioerger, E Hesper Rego and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Genomic Insight into Primary Adaptation ofAntibiotics (Basel, Switzerland) · 2025
    Article
  6. Metabolic Reprogramming ofJournal of proteome research · 2024
    Article
  7. Rhodamine 19 Alkyl Esters as Effective Antibacterial Agents.International journal of molecular sciences · 2024
    Article
  8. Effect of anti-biofilm peptideFrontiers in cellular and infection microbiology · 2024
    Article
  9. Saline-Alkali Soil Property Improved by the Synergistic Effects ofInternational journal of molecular sciences · 2023
    Article
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Skye R S FishbeinDepartment of Immunology and Infectious Disease, Harvard TH Chan School of Public Health, Boston, Massachusetts, 02115, United States.ORCID https://orcid.org/0000-0002-9554-1170
Francesca G TomasiDepartment of Immunology and Infectious Disease, Harvard TH Chan School of Public Health, Boston, Massachusetts, 02115, United States.
Ian D WolfDepartment of Immunology and Infectious Disease, Harvard TH Chan School of Public Health, Boston, Massachusetts, 02115, United States.
Charles L DulbergerDepartment of Immunology and Infectious Disease, Harvard TH Chan School of Public Health, Boston, Massachusetts, 02115, United States.
Albert WangDepartment of Immunology and Infectious Disease, Harvard TH Chan School of Public Health, Boston, Massachusetts, 02115, United States.
Hasmik KeshishianBroad Institute of MIT and Harvard, Cambridge, 02142, United States.
Luke WallaceBroad Institute of MIT and Harvard, Cambridge, 02142, United States.
Steven A CarrBroad Institute of MIT and Harvard, Cambridge, 02142, United States.
Thomas R IoergerDepartment of Computer Science and Engineering, Texas A&M University, Texas, 77843, United States.
E Hesper RegoDepartment of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, 06510, United States.ORCID https://orcid.org/0000-0002-2973-8354
Eric J RubinDepartment of Immunology and Infectious Disease, Harvard TH Chan School of Public Health, Boston, Massachusetts, 02115, United States erubin@hsph.harvard.edu.
Harvard University · USBroad Institute · USTexas A&M University · USYale University · US

Funding

VectorP30CA006516 · NCI · DANA-FARBER CANCER INSTITUTE · PI JENNIFER W MACK · 1985 to 2026
$330.6M
Vulnerabilities in Mycobacterial Cell-Wall BiogenesisP01AI095208 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SACCHETTINI, JAMES C · 2012 to 2022
$19.8M
The roles of genes critical for growth under defined conditions in vitro or duriU19AI107774 · NIAID · HARVARD SCHOOL OF PUBLIC HEALTH · PI CARR, STEVEN A, FORTUNE, SARAH · 2013 to 2017
$13.2M
"The molecular mechanisms of asymmetric cell division in mycobacteria."R01AI148255 · NIAID · YALE UNIVERSITY · PI REGO, ELIZABETH HESPER · 2020 to 2024
$2.1M
NCI NIH HHS P30 CA006516NIAID NIH HHS P01 AI095208NIAID NIH HHS R01 AI148255NIAID NIH HHS U19 AI107774
6 · The paper itself

Abstract

The recalcitrance of mycobacteria to antibiotic therapy is in part due to its ability to build proteins into a multi-layer cell wall. Proper synthesis of both cell wall constituents and associated proteins is crucial to maintaining cell integrity, and intimately tied to antibiotic susceptibility. How mycobacteria properly synthesize the membrane-associated proteome, however, remains poorly understood. Recently, we found that loss of

Identifiers

PMID33361193
PMCPMC8095456
OpenAlexW3117944658

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.