ArticleThe Journal of biological chemistry
CRAC channel opening is determined by a series of Orai1 gating checkpoints in the transmembrane and cytosolic regions.
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Article in The Journal of biological chemistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
1.4field-weighted citation impact, top 15% of its field
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Mechanistic insights into Orai dynamics during pore opening.Channels (Austin, Tex.) · 2026Review
- Evolutionarily conserved hydrophobicity and sterics in TM3/TM4 balance Orai1 pore opening.Protein science : a publication of the Protein Society · 2026Article
- Store-operated calcium entry-based targets for novel cancer therapeutic development.The Journal of pharmacology and experimental therapeutics · 2025Review
- Water in peripheral TM-interfaces of Orai1-channels triggers pore opening.Communications biology · 2024Article
- ORAI CaBiomolecules · 2024Review
- Synthetic Biology Meets CaCells · 2024Review
- Photocrosslinking-induced CRAC channel-like Orai1 activation independent of STIM1.Nature communications · 2023Article
- A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels.eLife · 2023Article
- CRAC and SK Channels: Their Molecular Mechanisms Associated with Cancer Cell Development.Cancers · 2022Review
- The Role of Lipids in CRAC Channel Function.Biomolecules · 2022Review
- Highlighting the Multifaceted Role of Orai1 N-Terminal- and Loop Regions for Proper CRAC Channel Functions.Cells · 2022Review
- STIM and Orai Mediated Regulation of Calcium Signaling in Age-Related Diseases.Frontiers in aging · 2022Review
- Orai1 Boosts SK3 Channel Activation.Cancers · 2021Article
- Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of CaCells · 2021Review
- Structural Insights into CaCells · 2021Review
- Defects in the STIM1 SOARα2 domain affect multiple steps in the CRAC channel activation cascade.Cellular and molecular life sciences : CMLS · 2021Article
- Isoform-Specific Properties of Orai Homologues in Activation, Downstream Signaling, Physiology and Pathophysiology.International journal of molecular sciences · 2021Review
- Endoplasmic Reticulum-Plasma Membrane Contact Sites as an Organizing Principle for Compartmentalized Calcium and cAMP Signaling.International journal of molecular sciences · 2021Review
- The Orai Pore Opening Mechanism.International journal of molecular sciences · 2021Review
- The Impact of Mutation L138F/L210F on the Orai Channel: A Molecular Dynamics Simulation Study.Frontiers in molecular biosciences · 2021Article
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Authors and funding
17 authors at 4 institutions in 3 countries.
Adéla TiffnerInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Romana SchoberInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Carmen HöglingerInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Daniel BonhenryCenter for Nanobiology and Structural Biology, Institute of Microbiology, Czech Academy of Sciences, Nove Hrady, Czechia.
Saurabh PandeyCenter for Nanobiology and Structural Biology, Institute of Microbiology, Czech Academy of Sciences, Nove Hrady, Czechia.
Victoria LunzInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Matthias SallingerInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Irene FrischaufInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Marc FahrnerInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Sonja LindingerInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Lena MaltanInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Sascha BerlanskyInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Michael StadlbauerInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Rainer SchindlGottfried Schatz Research Center, Medical University of Graz, Graz, Austria.
Rudiger EttrichCollege of Biomedical Sciences, Larkin University, Miami, Florida, USA; Faculty of Mathematics and Physics, Charles University, Prague, Czechia; Department of Cellular Biology & Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Christoph RomaninInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria.
Isabella DerlerInstitute of Biophysics, JKU Life Science Center, Johannes Kepler University Linz, Linz, Austria. Electronic address: Isabella.derler@jku.at.
Johannes Kepler University of Linz · ATCzech Academy of Sciences · CZFlorida International University · USMedical University of Graz · AT
Funding
Austrian Science Fund FWF P 27641Austrian Science Fund FWF P 28701Austrian Science Fund FWF P 30567Austrian Science Fund FWF P 32075Austrian Science Fund FWF P 32851Austrian Science Fund FWF P 32947Austrian Science Fund FWF W 1250
Abstract
The initial activation step in the gating of ubiquitously expressed Orai1 calcium (Ca
Indexed as
Calcium SignalingAmino Acid SubstitutionBacterial ProteinsBinding SitesCalciumGene Expression RegulationGenes, ReporterGenetic VectorsGreen Fluorescent ProteinsHEK293 CellsHumansIon Channel GatingLiposomesLuminescent ProteinsMolecular Dynamics SimulationMutation1-palmitoyl-2-oleoylphosphatidylcholineBacterial ProteinsCalciumenhanced cyan fluorescent proteinGreen Fluorescent ProteinsLiposomesLuminescent ProteinsNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanPhosphatidylcholinesRecombinant ProteinsSTIM1 protein, humanStromal Interaction Molecule 1yellow fluorescent protein, BacteriaAND-gateCRAC channelElectrophysiologyGatingGating checkpointsOpening-permissive conformationOrai1Signal propagationSTIM1
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.