Evidence map›Paper›PMID 33361149›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Extrasynaptic acetylcholine signaling through a muscarinic receptor regulates cell migration.

Mihoko Kato, Irina Kolotuev, Alexandre Cunha, Shahla Gharib, Paul W Sternberg

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Five newbioRxiv : the preprint server for biology · 2025
    Article
  5. The Role of Muscarinic Acetylcholine Receptor MInternational journal of molecular sciences · 2024
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Mihoko KatoDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Irina KolotuevElectron Microscopy Facility, University of Lausanne, Quartier Sorge-Biophore, CH-1015 Lausanne, Switzerland.ORCID 0000-0003-1433-8048
Alexandre CunhaCenter for Advanced Methods in Biological Image Analysis, California Institute of Technology, Pasadena, CA 91125.ORCID 0000-0002-2541-6024
Shahla GharibDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125.
Paul W SternbergDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125; pws@caltech.edu.ORCID 0000-0002-7699-0173
California Institute of Technology · USUniversity of Lausanne · CH

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Acetylcholine Receptors in Cell MigrationisR01HD091327 · NICHD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI KATO, MIHOKO, STERNBERG, PAUL WARREN · 2019 to 2023
$1.7M
Howard Hughes Medical InstituteNICHD NIH HHS R01 HD091327NIH HHS P40 OD010440
6 · The paper itself

Abstract

Acetylcholine (ACh) promotes various cell migrations in vitro, but there are few investigations into this nonsynaptic role of ACh signaling in vivo. Here we investigate the function of a muscarinic receptor on an epithelial cell migration in

Indexed as

AcetylcholineAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsCell MovementEpithelial CellsMuscle ContractionPresynaptic TerminalsReceptors, MuscarinicSignal TransductionAcetylcholineCaenorhabditis elegans ProteinsGAR-3 protein, C elegansReceptors, Muscarinicacetylcholinecell migrationmuscarinic receptor

Identifiers

PMID33361149
PMCPMC7817160
OpenAlexW3116272176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.