Evidence map›Paper›PMID 33361086›Full record

ArticleDisease models & mechanisms2020

L-type voltage-gated calcium channel agonists mitigate hearing loss and modify ribbon synapse morphology in the zebrafish model of Usher syndrome type 1.

Alaa Koleilat, Joseph A Dugdale, Trace A Christenson, Jeffrey L Bellah, Aaron M Lambert, Mark A Masino, Stephen C Ekker, Lisa A Schimmenti

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Mutation of the GDP-Fucose Biosynthesis GeneInternational journal of molecular sciences · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Glutamate Signaling via the AMPAR Subunit GluR4 Regulates Oligodendrocyte Progenitor Cell Migration in the Developing Spinal Cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Alaa KoleilatCollege of Continuing and Professional Studies, University of Minnesota, Minneapolis, MN 55108, USA.ORCID 0000-0001-7949-7205
Joseph A DugdaleDepartment of Otorhinolaryngology, Mayo Clinic, Rochester, MN 55905, USA.
Trace A ChristensonMayo Clinic Microscopy and Cell Analysis Core, Rochester, MN 55905, USA.
Jeffrey L BellahCenter for Clinical and Translational Science, Mayo Clinic, Rochester, MN 55905, USA.
Aaron M LambertDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Mark A MasinoDepartment of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Stephen C EkkerCenter for Clinical and Translational Science, Mayo Clinic, Rochester, MN 55905, USA.ORCID 0000-0003-0726-4212
Lisa A SchimmentiDepartment of Otorhinolaryngology, Mayo Clinic, Rochester, MN 55905, USA schimmenti.lisa@mayo.edu.ORCID 0000-0003-3154-4249
University of Minnesota · USMayo Clinic · USMayo Clinic in Florida · US

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Dopaminergic modulation of spinal locomotor circuitsR01NS094176 · NINDS · UNIVERSITY OF MINNESOTA · PI MASINO, MARK A · 2016 to 2020
$1.7M
NCATS NIH HHS UL1 TR000135NINDS NIH HHS R01 NS094176
6 · The paper itself

Abstract

The

Indexed as

AnimalsCalcium Channels, L-TypeDisease Models, AnimalEye ProteinsGuanylate KinasesHair Cells, AuditoryHearing LossLarvaMechanotransduction, CellularMutationMyosinsReflex, StartleStereociliaSwimmingSynapsesUsher SyndromesCalcium Channels, L-Typectbp2a protein, zebrafishEye ProteinsGuanylate KinasesMyo7aa protein, zebrafishMyosinsZebrafish ProteinsHair cellHearing lossmyo7aaRibbon synapseZebrafish

Identifiers

PMID33361086
PMCPMC7710014
OpenAlexW3107682855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.