ArticleJMIR mental health2020
Associations Among Internet Addiction, Genetic Polymorphisms, Family Functioning, and Psychopathological Risk: Cross-Sectional Exploratory Study.
Article in JMIR mental health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Positive association between Internet use and mental health among adults aged ≥50 years in 23 countries.Nature human behaviour · 2025Pooled it
- Targeting Internet Addiction Through Body Awareness Psychotherapy: The Mediating Role of Executive Functions and Emotion Regulation.Brain and behavior · 2025Trial
- Epigenetics of generalized internet use disorder including data on overuse of social media: a closer look at the SLC6A4, NR3C1 and OXT genes.BMC psychiatry · 2026Article
- Exploring the Comorbidity Mechanism of Internet Addiction, Insomnia, Depression, and Suicidality Among Chinese College Students Through Network Analysis.Alpha psychiatry · 2026Article
- Emotional Regulation as Relational Infrastructure: A Living Systems Perspective on the Capacity to Be Alone and Collective Care.International journal of environmental research and public health · 2026Article
- Associations of excessive smartphone duration and unlock frequency with non-suicidal self-injury in college students.World journal of psychiatry · 2026Article
- Disordered eating in early childhood: DRD2 and COMT gene polymorphisms and behavioral features in family trios.Eating and weight disorders : EWD · 2026Article
- Adolescent Insomnia Disorder - Problematic Internet Use Nexus: A Convergent Developmental Trajectory - Bridging Neuroimaging Biomarkers, Molecular Susceptibility, and Environmental-Neurocognitive Cascades.Psychology research and behavior management · 2026Review
- Cross-lagged analysis of depression symptoms and internet addiction tendencies among first-year university students and the moderating effects of urban-rural background and sibling status.Frontiers in psychiatry · 2026Article
- Early Screen Exposure and Preadolescent Outcomes: A Longitudinal Follow-Up on Dysregulation, Academic Achievements, and Capacity to Be Alone.Children (Basel, Switzerland) · 2025Article
- The Association Between Presleep and Postwake Mobile Phone Use and Nonsuicidal Self-Injury Among University Students: Cross-Sectional Study.Journal of medical Internet research · 2025Article
- Psychopathological Risk During Adolescent Study-Abroad: A Larger-Cohort Update of a Previous Longitudinal Study.European journal of investigation in health, psychology and education · 2025Article
- Recent Developments in Eating Disorders in Children: A Comprehensive Perspective.Journal of clinical medicine · 2025Article
- Body dissatisfaction, drive for thinness, and psychopathological symptoms in preadolescents who use Instagram.Eating and weight disorders : EWD · 2025Article
- Unraveling the Complexity of Internet Addiction: A Multi-Faceted Perspective from Five Key Studies.Journal of clinical medicine · 2025Article
- Integrating Screens and Spoons: An Exploratory Study on Digital Technology's Influence on Parent-Child Interactions.European journal of investigation in health, psychology and education · 2025Article
- The Role of Parental and Adolescent Psychosocial Factors in Different Aggression Profiles: A Comparative Approach.Journal of clinical medicine · 2025Article
- Patterns of smartphone dependence and predictive factors in Chinese college freshmen: a latent profile analysis.Frontiers in psychology · 2025Article
- Similarities and Differences in Genetics.Advances in experimental medicine and biology · 2025Review
- Internet addiction: the Czech and Slovak adolescent population.BMC psychology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInternational research has emphasized that youths are at higher risk for the onset of internet addiction (IA), but studies investigating biological, psychological, and social factors associated with this condition are limited.
objectiveThis study aims to investigate the possible association between IA and genetic polymorphisms in monoamine oxidase A (MAO-A), serotonin-transporter (5-HTTPR), dopamine receptor (DRD4), and dopamine transporter (DAT1) genes by considering the role played by the perception of young adults in their family functioning and their depression, anxiety, and avoidant personality problems.
methodsIn a sample of 104 male and female young adults aged between 19 and 23 years (mean age 21.87, SD 2.29 years) recruited from universities in the central southern part of Italy, we addressed the presence of IA using the Young criteria of the IA test. Moreover, the perception of young adults of their family functioning and their psychopathological symptoms were assessed through the Family Assessment Device (FAD) and the Adult Self-Report, respectively.
resultsWe found no significant association between IA and any genetic polymorphisms, neither among males or females. Young adults with IA reported significantly higher scores in the subscale of FAD affective responsiveness (AR; P=.01) and in depressive problems (P=.02), anxiety problems (P=.009), and avoidant personality problems (P=.003) than those in the control group. Results of mediation analyses showed a mediation role played by depressive symptoms (B=0.99; 95% CI 0.22 to 1.97) and avoidant personality problems (B=1.09; 95% CI 0.32 to 2.05) of young adults on the relationship between the FAD, AR, and IA. Finally, this relationship was moderated by the genotype of the 5-HTTLPR (P<.001), DAT1 (P<.001), and MAO-A (P<.001) genes in young adults.
conclusionsThis exploratory study supports the recent evidence on the mutual relationship among biological, individual, and social risk factors associated with IA in young adulthood. Our findings may have important clinical implications for the development of prevention and treatment programs.
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