Evidence map›Paper›PMID 33360831›Full record

ArticleComputers in biology and medicine2021

A computational drug repurposing approach in identifying the cephalosporin antibiotic and anti-hepatitis C drug derivatives for COVID-19 treatment.

Raj Kumar, Vikas Kumar, Keun Woo Lee

Open access · greenAbstract read
In one paragraph

Article in Computers in biology and medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 36 citations in OpenAlex.

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  5. AI and data science for smart emergency, crisis and disaster resilience.International journal of data science and analytics · 2023
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  9. Structural chemistry · 2022
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  10. Article
  11. A review of the latest research on MRSC medicinal chemistry · 2021
    Review
  12. International journal of molecular sciences · 2021
    Article
  13. Article
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Raj KumarDepartment of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat, Solan, Himachal Pradesh, 173 234, India. Electronic address: raj.kumar@juit.ac.in.
Vikas KumarDivision of Life Science, Department of Bio & Medical Big Data (BK21 Four Program), Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Research Institute of Natural Science (RINS), Gyeongsang National University (GNU), 501 Jinju-daero, Jinju, 52828, Republic of Korea.
Keun Woo LeeDivision of Life Science, Department of Bio & Medical Big Data (BK21 Four Program), Plant Molecular Biology and Biotechnology Research Center (PMBBRC), Research Institute of Natural Science (RINS), Gyeongsang National University (GNU), 501 Jinju-daero, Jinju, 52828, Republic of Korea. Electronic address: kwlee@gnu.ac.kr.
Gyeongsang National University · KRJaypee University of Information Technology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over 1.4 million deaths worldwide. Repurposing existing drugs offers the fastest opportunity to identify new indications for existing drugs as a stable solution against coronavirus disease 2019 (COVID-19). The SARS-CoV-2 main protease (M

Indexed as

Coronavirus 3C ProteasesCOVID-19 Drug TreatmentDrug RepositioningMolecular Dynamics SimulationSARS-CoV-2CeftarolineCephalosporinsCOVID-19HepacivirusHepatitis CHumansOligopeptides3C-like proteinase, SARS-CoV-2CeftarolineCephalosporinsCoronavirus 3C ProteasesOligopeptidestelaprevirCOVID-19Drug repurposingFree energy calculationsMolecular dynamicsSARS-CoV-2Virtual screening

Identifiers

PMID33360831
PMCPMC7748973
OpenAlexW3115357180

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.