Evidence map›Paper›PMID 33360643›Full record

ArticleGait & posture2021

Comparison of forward and backward postural perturbations in mild-to-moderate Parkinson's disease.

Chiahao Lu, Sommer L Amundsen-Huffmaster, Kenneth H Louie, Robert Lowe, Reme Abulu, Robert A McGovern, Jerrold L Vitek, Colum D MacKinnon, Scott E Cooper

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gait & posture, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.2field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Chiahao LuDepartment of Neurology, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN, 55455, United States. Electronic address: luxxx214@umn.edu.
Sommer L Amundsen-HuffmasterDepartment of Neurology, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN, 55455, United States.
Kenneth H LouieDepartment of Biomedical Engineering, University of Minnesota, 7-105 Hasselmo Hall, 312 Church Street SE, Minneapolis, MN, 55455, United States.
Robert LoweDepartment of Neurology, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN, 55455, United States.
Reme AbuluDepartment of Neurology, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN, 55455, United States.
Robert A McGovernDepartment of Neurosurgery, University of Minnesota, 420 Delaware Street SE, Minneapolis, MN, 55455, United States.
Jerrold L VitekDepartment of Neurology, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN, 55455, United States.
Colum D MacKinnonDepartment of Neurology, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN, 55455, United States.
Scott E CooperDepartment of Neurology, University of Minnesota, 516 Delaware Street SE, Minneapolis, MN, 55455, United States.
University of Minnesota · US

Funding

Pathophysiology-based approaches to deep brain stimulation for Parkinson's diseaseP50NS098573 · NINDS · UNIVERSITY OF MINNESOTA · PI EBERLY, LYNN E · 2016 to 2020
$9.1M
Spatiotemporal Optimization of Deep Brain Stimulation for Parkinson's DiseaseR01NS094206 · NINDS · UNIVERSITY OF MINNESOTA · PI Matthew Douglas Johnson, THEODEN I NETOFF · 2016 to 2026
$5.6M
Algorithms for programming deep brain stimulation systemsR01NS081118 · NINDS · UNIVERSITY OF MINNESOTA · PI HAREL, NOAM, JOHNSON, MATTHEW DOUGLAS · 2012 to 2023
$4.0M
Predictors of progression to freezing of gait in Parkinson's diseaseR01NS088679 · NINDS · UNIVERSITY OF MINNESOTA · PI MACKINNON, COLUM D · 2015 to 2018
$1.6M
NINDS NIH HHS P50 NS098573NINDS NIH HHS R01 NS081118NINDS NIH HHS R01 NS088679NINDS NIH HHS R01 NS094206
6 · The paper itself

Abstract

backgroundAssessing postural stability in Parkinson's disease (PD) often relies on measuring the stepping response to an imposed postural perturbation. The standard clinical technique relies on a brisk backwards pull at the shoulders by the examiner and judgement by a trained rater. In research settings, various quantitative measures and perturbation directions have been tested, but it is unclear which metrics and perturbation direction differ most between people with PD and controls.

objectives(1) Use standardized forward vs. backward perturbations of a support surface to evaluate reactive stepping performance between PD and control participants. (2) Evaluate the utility of using principal components analysis to capture the dynamics of the reactive response and differences between groups.

methodsSixty-two individuals participated (40 mild-to-moderate PD, off medication). Standardized rapid translations of the support surface were applied, requiring at least one step, backward or forward, to restore balance. The number of steps taken and the projection of the first principal component (PC1) of the center of pressure (COP) time series were entered in linear repeated-measures mixed effect models.

resultsForward falls required significantly fewer steps to recover than backward falls. PC1 captured more than half of the variance in the COP trajectory. Analysis of the PC1 projection revealed a significant interaction effect of group (PD vs. controls) by direction, such that there was a group difference in forward stepping, but not backward. SIGNIFICANCE: Forward reactive stepping in PD differed from controls more than backward-stepping. PC1 projections of the COP trajectory capture the dynamics of the postural response and differ between PD and controls.

Indexed as

FemaleHumansMaleParkinson DiseasePostural BalanceCenter of pressureParkinson’s diseasePostural instabilityPrincipal component analysisReactive stepping

Identifiers

PMID33360643
PMCPMC7902457
OpenAlexW3114467260

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.