Evidence map›Paper›PMID 33360365›Full record

Trial reportJournal of affective disorders2021

Development and Open Trial of a Technology-Enhanced Family Intervention for Adolescents at Risk for Mood Disorders.

David J Miklowitz, Marc J Weintraub, Filippo Posta, Patricia D Walshaw, Samantha J Frey, Georga M Morgan-Fleming, Catherine A Wilkerson, Danielle M Denenny, Armen A Arevian

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03913013 (Technology-Enhanced Family-Focused Treatment for Adolescents at High Risk for Mood Disorders), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03913013 phase1 / phase2completednot on this map

Technology-Enhanced Family-Focused Treatment for Adolescents at High Risk for Mood Disorders

TypeinterventionalSponsorUniversity of California, Los AngelesRan2018 to 2021Enrolled65ConditionsMood Disorders, Bipolar Disorder, Major DepressionArmsFamily-Focused Treatment with MCC App
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. A Systematic Review of Mobile Apps as an Adjunct to Psychological Interventions for Emotion Dysregulation.International journal of environmental research and public health · 2023
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

David J MiklowitzDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA. Electronic address: dmiklowitz@mednet.ucla.edu.
Marc J WeintraubDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA.
Filippo PostaEstrella Mountain Community College, Avondale, AZ.
Patricia D WalshawDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA.
Samantha J FreyDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA.
Georga M Morgan-FlemingDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA.
Catherine A WilkersonDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA.
Danielle M DenennyDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA.
Armen A ArevianDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA.
University of California, Los Angeles · USEstrella Mountain Community College · US

Funding

The Role of Social Networks in Treatment Engagement for MinoritiesP30MH082760 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIRANDA, JEANNE · 2008 to 2012
$8.6M
Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy TrialR01MH123575 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, MIKLOWITZ, DAVID JAY · 2020 to 2023
$5.4M
Neurodevelopment and Psychosis in the 22q11.2 Copy Number VariantsR37MH085953 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARRIE E BEARDEN · 2023 to 2026
$2.9M
Technology-Enhanced Family-Focused Treatment for Adolescents at High Risk for Mood DisordersR34MH117200 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AREVIAN, ARMEN C, MIKLOWITZ, DAVID JAY · 2018 to 2020
$933k
NIMH NIH HHS P30 MH082760NIMH NIH HHS R01 MH123575NIMH NIH HHS R34 MH117200NIMH NIH HHS R37 MH085953
6 · The paper itself

Abstract

aimIntegrating psychosocial interventions with mobile apps may increase treatment engagement among adolescents. We examined the user experience, uptake, and clinical effects of a mobile-enhanced family-focused therapy (FFT) among adolescents at risk for mood disorders.

methodWe created a mobile app containing 12 lesson plans corresponding to content of weekly FFT sessions, with modules concerning mood management, family communication and problem-solving. We pilot tested the app in an open trial of FFT (12 sessions in 18 weeks) for adolescents who had active depressive or hypomanic symptoms, a parent with mood disorder, and at least one parent who expressed high levels of criticism. Teens and parents made daily and weekly ratings of youths' moods, amount of parent/offspring criticism, and practice of FFT psychoeducational, communication or problem-solving skills. Independent evaluators interviewed adolescents at baseline and every 9 weeks over 27 weeks to measure symptom trajectories.

resultsParticipants were adolescents (n=22; mean age 15.4 ± 1.8 years; 45.5% female) and their 34 parents. Completion of requested app assessment and skill practices averaged 46%-65% among adolescents and parents over 18 weeks of treatment. Adolescents showed significant improvement in clinician-rated depression scores over 27 weeks (Cohen's d=1.58, 95% CI, 0.83 to 2.32) and reported reductions in the amount of perceived criticism expressed by parents. LIMITATIONS: The uncontrolled design limits inferences about whether the mobile app augmented the effects of FFT on moods or family relationships.

conclusionsMobile applications may enhance users' responses to family therapy and provide clinicians with information regarding clinical status. Clinicaltrials.gov NCT03913013.

Indexed as

Bipolar DisorderMood DisordersAdolescentFamily TherapyFemaleHumansMaleTechnologyTreatment Outcomebipolar disorderDigital mental healthearly interventionexpressed emotionmobile apps

Identifiers

PMID33360365
PMCPMC8068558
OpenAlexW3110784846

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.