ArticleEnvironment international2021
Incidence of uterine leiomyoma in relation to urinary concentrations of phthalate and phthalate alternative biomarkers: A prospective ultrasound study.
Article in Environment international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Assessment of ovarian dysfunction induced by environmental toxins: a systematic review.Frontiers in public health · 2025Pooled it
- Associations of Serum Per- and Polyfluoroalkyl Substance Concentrations with Dyslipidemia and Its Subtypes in an Adult Population from Shandong, East China.Environment & health (Washington, D.C.) · 2026Article
- Estrogenic activity in tampon products.Journal of the Endocrine Society · 2026Article
- Use of chemical hair straighteners in relation to incidence and growth of uterine leiomyomata: a prospective ultrasound study.American journal of epidemiology · 2026Article
- A prospective study of hair dyes and uterine leiomyomata incidence in the study of environment, lifestyle, and fibroids.Fertility and sterility · 2026Article
- IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Phthalates disrupt female reproductive health: a call for enhanced investigation into mixtures.Reproduction (Cambridge, England) · 2025Review
- Silicone wristbands reveal ubiquitous human exposure to ortho-phthalates and non-ortho-phthalate plasticizers in Southern California.Environmental research · 2024Article
- Sex-specific associations of a ferroalloy metal mixture with motor function in Italian adolescents.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Hair product use and urinary biomarker concentrations of non-persistent endocrine disrupting chemicals among reproductive-aged Black women.Chemosphere · 2024Article
- Non-persistent endocrine disrupting chemical mixtures and uterine leiomyomata in the study of environment, lifestyle and fibroids (SELF).Chemosphere · 2024Article
- Risk perception and use of personal care products by race and ethnicity among a diverse population.UCL open. Environment · 2024Article
- Associations of Pregnancy Per- and Polyfluoroalkyl Substance Concentrations and Uterine Fibroid Changes across Pregnancy: NICHD Fetal Growth Studies - Singletons Cohort.Environmental health perspectives · 2023Article
- Associations of individual and cumulative urinary phthalate and replacement biomarkers with gestational weight gain through late pregnancy.The Science of the total environment · 2023Article
- Urinary phthalate metabolite concentrations and hot flash outcomes: Longitudinal associations in the Midlife Women's Health Study.Environmental research · 2023Article
- The adverse role of endocrine disrupting chemicals in the reproductive system.Frontiers in endocrinology · 2023Review
- Association of Exposure to Phthalate Metabolites With Sex Hormones, Obesity, and Metabolic Syndrome in US Women.JAMA network open · 2022Article
- Correlates of non-persistent endocrine disrupting chemical mixtures among reproductive-aged Black women in Detroit, Michigan.Chemosphere · 2022Article
- Midlife Urinary Phthalate Metabolite Concentrations and Prior Uterine Fibroid Diagnosis.International journal of environmental research and public health · 2022Article
- Imputation of Below Detection Limit Missing Data in Chemical Mixture Analysis with Bayesian Group Index Regression.International journal of environmental research and public health · 2022Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundNumerous studies suggest that some phthalates have adverse reproductive effects. However, literature on the association between phthalates and incidence of uterine leiomyomata (UL) is limited and inconsistent, with no existing prospective studies.
objectivesWe examined the association of urinary concentrations of phthalate and phthalate alternative biomarkers with UL incidence.
methodsWe conducted a case-cohort analysis within a subgroup of 754 participants in the Study of the Environment, Lifestyle, and Fibroids (SELF), a prospective cohort of premenopausal Black women aged 23-35 years who were recruited during 2010-2012. We quantified fourteen phthalates and two phthalate alternative [1,2-cyclohexane dicarboxylic acid, diisononyl ester (DINCH)] biomarkers in urine collected at baseline, 20 months, and 40 months. Transvaginal ultrasounds identified UL at baseline and every 20 months during 60 months of follow-up. We evaluated the individual biomarkers, molar sum of di(2-ethylhexyl) phthalate [ΣDEHP] and potency-weighted sum of anti-androgenic [WΣAA] biomarkers. We used Cox proportional hazards regression to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between biomarkers and UL incidence. We then used quantile g-computation to examine joint associations of multiple phthalate biomarkers with UL incidence.
resultsMost individual biomarkers showed weak-to-moderate inverse associations with UL incidence. HRs comparing highest vs. lowest quartiles of mono-isobutyl phthalate (MiBP) and mono-hydroxyisobutyl phthalate (MHiBP) concentrations were 0.63 (95% CI: 0.40, 1.01) and 0.61 (95% CI: 0.38, 0.96), respectively. Inverse associations for specific phthalates were stronger among women with BMI ≥ 30 kg/m DISCUSSION: In this prospective ultrasound study of reproductive-aged Black women, urinary concentrations of phthalate and DINCH biomarkers were not appreciably associated with higher risk of UL, either individually or jointly.
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