ArticleCortex; a journal devoted to the study of the nervous system and behavior2021
Functional thalamocortical connectivity at term equivalent age and outcome at 2 years in infants born preterm.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Altered connectivity and network efficiency in preterm infants.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Division-Specific Organization of a Shared Functional Scaffold in the Early-Life Human Brain.bioRxiv : the preprint server for biology · 2026Article
- Prediction of motor developmental outcomes based on MRI radiomics in premature infants.Pediatric research · 2026Article
- The influence of family care guidance for premature infants based on a telemedicine model on their neurodevelopmental assessment indicators.Frontiers in pediatrics · 2026Article
- Functional Connectivity Relationships to Longitudinal Motor Outcomes Differ in Very Preterm Children With and Without Brain Injury.Neurology. Clinical practice · 2025Article
- Functional organization of the neonatal thalamus across development depicted by functional MRI.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Altered brain state dynamics between preterm and term-born infants.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional connectivity as a prognostic biomarker for neurodevelopmental outcomes in preterm infants without severe brain injury.Brain communications · 2025Article
- Perinatal development of structural thalamocortical connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Longitudinal functional brain connectivity maturation in premature newborn infants: Modulatory influence of early music enrichment.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- A shifting role of thalamocortical connectivity in the emergence of cortical functional organization.Nature neuroscience · 2024Article
- Article
- Fetal development of functional thalamocortical and cortico-cortical connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Development of neonatal brain functional centrality and alterations associated with preterm birth.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- Spatiotemporal Developmental Gradient of Thalamic Morphology, Microstructure, and Connectivity fromthe Third Trimester to Early Infancy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Phase-Based Cortical Synchrony Is Affected by Prematurity.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Neonatal motor functional connectivity and motor outcomes at age two years in very preterm children with and without high-grade brain injury.NeuroImage. Clinical · 2022Article
- Neonatal amygdala resting-state functional connectivity and socio-emotional development in very preterm children.Brain communications · 2022Article
- Microstructural Measures of the Inferior Longitudinal Fasciculus Predict Later Cognitive and Language Development in Infants Born With Extremely Low Birth Weight.Journal of child neurology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Infants born preterm are at high risk of long-term motor and neurocognitive deficits. In the majority of these infants structural MRI at the time of normal birth does not predict motor or cognitive outcomes accurately, and many infants without apparent brain lesions later develop motor and cognitive deficits. Thalamocortical connections are known to be necessary for normal brain function; they develop during late fetal life and are vulnerable to perinatal adversity. This study addressed the hypothesis that abnormalities in the functional connectivity between cortex and thalamus underlie neurocognitive impairments seen after preterm birth. Using resting state functional connectivity magnetic resonance imaging (fMRI) in a group of 102 very preterm infants without major focal brain lesions, we used partial correlations between thalamus and functionally-derived cortical areas to determine significant connectivity between cortical areas and thalamus, and correlated the parameter estimates of these connections with standardised neurocognitive assessments in each infant at 20 months of age. Pre-motor association cortex connectivity to thalamus correlates with motor function, while connectivity between primary sensory-motor cortex and thalamus correlates with cognitive scores. These results demonstrate the importance and vulnerability of functional thalamocortical connectivity development in the perinatal period for later neurocognitive functioning.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.