ArticleJournal of affective disorders2021
Concurrent and prospective associations of obsessive-compulsive symptoms with suicidality in young adults: A genetically-informative study.
Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Initial evaluation of a therapist-supported online cognitive therapy self-help for patients with taboo obsessions.The British journal of clinical psychology · 2022Trial
- Are There Causal Associations Between Obsessive-Compulsive Disorder and Cardiometabolic Phenotypes? A Genetic Correlation and Bi-Directional Mendelian Randomization Study.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2026Article
- Sexuality and Related Disorders in OCD and Their Symptoms.Journal of clinical medicine · 2025Review
- Biomarkers of Obsessive-Compulsive Disorder Subtypes: A Literature Review.International journal of molecular sciences · 2025Review
- Obsessive-compulsive disorder and suicide: a longitudinal study in Taiwan.Epidemiology and psychiatric sciences · 2024Article
- Associations Between Suicidality and Interoception in Obsessive-Compulsive Disorder.Journal of obsessive-compulsive and related disorders · 2023Article
- Prevalence and correlates of lifetime suicide attempt in obsessive-compulsive disorder with major depression.Journal of psychiatric research · 2023Article
- Association of Obsessive-Compulsive Disorder and Obsessive-Compulsive Symptoms With Substance Misuse in 2 Longitudinal Cohorts in Sweden.JAMA network open · 2022Article
- Suicidal Ideation and Obsessive-Compulsive Disorder: Links and Knowledge.Psychology research and behavior management · 2022Review
- The associations of obsessive-compulsive symptom dimensions and general severity with suicidal ideation in patients with obsessive-compulsive disorder: The role of specific stress responses to COVID-19.Clinical psychology & psychotherapy · 2021Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundObsessive-compulsive disorder (OCD) has been linked with elevated risk of suicidality. However, most previous studies have been cross-sectional, and little is known about the aetiology of the association between obsessive-compulsive symptoms (OCS) and suicidality in young adults.
methodsParticipants were members of the Child and Adolescent Twin Study in Sweden, at ages 18 (n = 9,162) and 24 (n = 3,466). Twins completed self-report measures, including assessment of OCS, suicidal ideation, and suicidal attempts. Logistic regression models tested concurrent and prospective associations of total OCS and OCS dimensions with suicidality, with and without adjustment for depression and anxiety symptoms. Genetic models tested the extent to which the main phenotypic associations were accounted for by genetic and environmental influences.
resultsTotal OCS were significantly associated with concurrent reports of suicidality at age 18 and 24, even when controlling for depressive and anxiety symptoms. Taboo obsessions (e.g., sexual and aggressive thoughts) were more robustly associated with suicidality than other OCS dimensions, and prospectively predicted suicidality symptoms over time, even when controlling for baseline suicide attempts. Genetic factors accounted for most of the concurrent and longitudinal covariance between OCS and suicidality, with substantial non-shared environmental influences. LIMITATIONS: We relied on self-report measures and did not include diagnostic assessment of OCD.
conclusionsOCS, particularly taboo obsessions, are associated with significantly elevated risk of suicidality in late adolescence and early adulthood. This relationship is explained by a combination of common genetic liability and non-shared environmental effects, suggesting that effective OCS treatment might reduce suicidality risk in this group.
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