ArticleNeuroscience letters2021
Neurofilament light plasma concentration positively associates with age and negatively associates with weight and height in the dog.
Article in Neuroscience letters, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed.
- Investigation of Serum Neurofilament Light Chain as a Surrogate for Cerebrospinal Fluid Neurofilament Light Chain in Canine Cognitive Dysfunction Syndrome.Animals : an open access journal from MDPI · 2026Article
- Advances in biomarker discovery for canine cognitive dysfunction: a comprehensive structured narrative review and future perspectives.Veterinary research communications · 2026Review
- Establishing a standardized biorepository across 3 clinical and translational science center-affiliated veterinary institutions is feasible and productive.American journal of veterinary research · 2026Article
- Cognitive Improvement and Microbiota-Gut-Brain Axis Regulation byMicroorganisms · 2026Article
- Nutrition Research in Aging Dogs and Cats: What We Know and What We Need to Do.Animals : an open access journal from MDPI · 2026Review
- Neurofilament light chain may serve as a cross-species blood biomarker to assess aging and predict mortality.PLoS biology · 2026Article
- Plasma and cerebrospinal fluid biomarkers in aged dogs with cognitive decline.BMC veterinary research · 2025Article
- Diagnostic and Prognostic Value of Serum Neurofilament Light Chain in Canine Spinal Cord Diseases.Veterinary sciences · 2025Article
- The companion dog as a translational model for Alzheimer's disease: Development of a longitudinal research platform and post mortem protocols.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Neurofilament light chain (Nf-L) in cerebrospinal fluid and serum as a potential biomarker in the differential diagnosis of neurological diseases in cattle.Veterinary research · 2025Article
- Neurofilament light chain concentration does not correlate with disease status in Labrador Retrievers affected with idiopathic laryngeal paralysis.American journal of veterinary research · 2024Article
- Plasma Neurofilament Light Chains as Blood-Based Biomarkers for Early Diagnosis of Canine Cognitive Dysfunction Syndrome.International journal of molecular sciences · 2023Article
- Association between neurofilament light chain concentration and lesion size in dogs with meningoencephalitis of unknown origin.Veterinary medicine and science · 2023Article
- Cerebrospinal fluid and serum proteomic profiles accurately distinguish neuroaxonal dystrophy from cervical vertebral compressive myelopathy in horses.Journal of veterinary internal medicine · 2023Article
- Preliminary study of neurofilament light chain as a biomarker for hypoxia-induced neuronal injury in dogs.Frontiers in veterinary science · 2023Article
- Neurofilament Proteins as Biomarkers to Monitor Neurological Diseases and the Efficacy of Therapies.Frontiers in neuroscience · 2021Review
- Evaluation of neurofilament light chain as a biomarker in dogs with structural and idiopathic epilepsy.Journal of veterinary internal medicineArticle
- Use of neurofilament light chain to identify structural brain diseases in dogs.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Plasma neurofilament light chain (pNfL) concentration is a biomarker for neuroaxonal injury and degeneration and can be used to monitor response to treatment. Spontaneous canine neurodegenerative diseases are a valuable comparative resource for understanding similar human conditions and as large animal treatment models. The features of pNfL concentration in healthy dogs is not well established. We present data reporting basic pNfL concentration trends in the Labrador Retriever breed. Fifty-five Labrador Retrievers were enrolled. pNfL concentration was measured and correlated to age, sex, neuter status, height, weight, body mass index, and coat color. We found increased pNfL with age (P < 0.0001), shorter stature (P = 0.009) and decreased body weight (P < 0.001). These are similar to findings reported in humans. pNfL concentration did not correlate with sex, BMI or coat color. This data further supports findings that pNfL increase with age in a canine population but highlights a need to consider weight and height when determining normal pNfL concentration in canine populations.
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Registered trials
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