Evidence map›Paper›PMID 33359714›Full record

ArticleAmerican journal of ophthalmology2021

Rates of RNFL Thinning in Patients with Suspected or Confirmed Glaucoma Receiving Unilateral Intravitreal Injections for Exudative AMD.

Swarup S Swaminathan, Anne L Kunkler, Ann V Quan, Charles M Medert, Elizabeth A Vanner, William Feuer, Ta Chen Chang

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Swarup S SwaminathanBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA. Electronic address: sswaminathan@miami.edu.
Anne L KunklerBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Ann V QuanBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Charles M MedertBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Elizabeth A VannerBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
William FeuerBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.
Ta Chen ChangBascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Funding

Miami Clinical and Translational Science InstituteUL1TR002736 · NCATS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, KOBETZ, ERIN N · 2018 to 2022
$23.2M
Shared Equipment ModuleP30EY014801 · NEI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Dmitry V Ivanov · 2004 to 2026
$12.2M
NCATS NIH HHS UL1 TR002736NEI NIH HHS P30 EY014801
6 · The paper itself

Abstract

purposeThis study evaluated whether the rate of retinal nerve fiber layer (RNFL) thinning is faster in eyes receiving intravitreal injections than in fellow uninjected eyes among patients suspected of having or confirmed to have glaucoma and exudative age-related macular degeneration (AMD).

designRetrospective comparative cohort study.

methodsPatients with a diagnosis of unilateral exudative AMD and confirmed to have or suspected of having glaucoma in both eyes receiving unilateral intravitreal injections were identified. Those with ≥3 RNFL optical coherence tomography scans and ≥6 injections were included in the study. Rates of RNFL thinning in the injected eye versus the uninjected eye were estimated using linear mixed models. The main outcome measurement was the differences in rates of RNFL thinning in the injected versus the fellow uninjected eye. The effects of postinjection elevation of intraocular pressure (IOP), injection frequency, and number of injections were also evaluated.

resultsA total of 53 patients met the inclusion criteria, receiving 26.4 ± 15.9 intravitreal injections. The average rate of RNFL thinning in uninjected eyes was -0.620 μm/year (P = .029). Injected eyes had an additional incremental loss of -0.385 μm/year, but this value was not statistically significant (95% confidence interval [CI]: -1.147 to 0.379 μm/year; P = .324). Subgroup analysis with only glaucoma patients (n = 33) also demonstrated a nonsignificant effect of injections (-0.568 μm/year; 95% CI: -1.454 to 0.319 μm/year; P = .212). Postinjection IOP elevation, injection frequency, and total number of injections were not associated with faster RNFL loss.

conclusionsAmong exudative AMD patients with glaucoma or suspected of having glaucoma, the rate of RNFL thinning in eyes receiving intravitreal injections did not significantly differ from that of fellow uninjected eyes.

Indexed as

AgedAged, 80 and overAngiogenesis InhibitorsExudates and TransudatesFemaleGlaucoma, Open-AngleHumansIntraocular PressureIntravitreal InjectionsMaleNerve FibersOcular HypertensionRetinal Ganglion CellsRetrospective StudiesTomography, Optical CoherenceTonometry, OcularAngiogenesis InhibitorsVascular Endothelial Growth Factor AVEGFA protein, human

Identifiers

PMID33359714
PMCPMC8222411

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