Evidence map›Paper›PMID 33359586›Full record

ArticleThe journal of allergy and clinical immunology. In practice2021

African American Children Are More Likely to Be Allergic to Shellfish and Finfish: Findings from FORWARD, a Multisite Cohort Study.

Mahboobeh Mahdavinia, Mary C Tobin, Jamie L Fierstein, Aame B Andy-Nweye, Lucy A Bilaver, Susan Fox, Andrea A Pappalardo, Jialing Jiang, Perry A Catlin, Annika Chura and 11 more

Open access · greenAbstract readMulticenter Study
In one paragraph

Article in The journal of allergy and clinical immunology. In practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 42 citations in OpenAlex.

  1. Review
  2. Article
  3. The age of eczema onset and multiple food allergies.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2026
    Article
  4. Review
  5. Review
  6. Distinct skin microbiome signatures in Black and White children with food allergy and asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025
    Article
  7. Article
  8. Article
  9. The impact of the COVID-19 pandemic on multicultural families with food allergy.The journal of allergy and clinical immunology. Global · 2025
    Article
  10. Total Serum IgE in a Cohort of Children With Food Allergy.The journal of allergy and clinical immunology. In practice · 2025
    Observational
  11. Disparities in pediatric seafood allergy by social determinants of health.The journal of allergy and clinical immunology. In practice · 2025
    Article
  12. Differences in familiarity with oral immunotherapy among caregivers of White and Black children with food allergy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024
    Article
  13. Addressing Health Equity in Food Allergy.The journal of allergy and clinical immunology. In practice · 2024
    Article
  14. Gut microbiome is associated with asthma and race in children with food allergy.The Journal of allergy and clinical immunology · 2023
    Article
  15. Understanding how socioeconomic determinants affect the development of allergy to common foods in children.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023
    Article
  16. Multi-omics profiling approach in food allergy.The World Allergy Organization journal · 2023
    Review
  17. Assessing Disparities in the Prevalence of Atopic Comorbidities Among Food-Allergic Children.The journal of allergy and clinical immunology. In practice · 2023
    Article
  18. Article
  19. Food Allergies in Inner-City Schools: Addressing Disparities and Improving Management.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Review
  20. Sensitization to house dust mite and cockroach may mediate the racial difference in shellfish allergy.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 1 country.

Mahboobeh MahdaviniaDivision of Allergy/Immunology, Rush University Medical Center, Chicago, Ill. Electronic address: Mahboobeh_mahdavinia@rush.edu.
Mary C TobinDivision of Allergy/Immunology, Rush University Medical Center, Chicago, Ill.
Jamie L FiersteinCenter for Food Allergy and Asthma Research and Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Aame B Andy-NweyeDivision of Allergy/Immunology, Rush University Medical Center, Chicago, Ill.
Lucy A BilaverCenter for Food Allergy and Asthma Research and Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Susan FoxDivision of Allergy/Immunology, Rush University Medical Center, Chicago, Ill.
Andrea A PappalardoDepartment of Medicine and Pediatrics, University of Illinois at Chicago, Chicago, Ill.
Jialing JiangCenter for Food Allergy and Asthma Research and Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Perry A CatlinDivision of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Annika ChuraDivision of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Adam RobinsonDivision of Allergy and Immunology, Children's National Health Systems, Washington, DC.
Iman AbdikarimDivision of Allergy and Immunology, Children's National Health Systems, Washington, DC.
Amaziah ColemanDivision of Allergy and Immunology, Children's National Health Systems, Washington, DC.
Christopher M WarrenAdvanced General Pediatrics and Primary Care, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
Pamela J NewmarkCenter for Food Allergy and Asthma Research and Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Alexandria BozenCenter for Food Allergy and Asthma Research and Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Olivia R NegrisCenter for Food Allergy and Asthma Research and Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Jacqueline A PongracicAdvanced General Pediatrics and Primary Care, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
Hemant P SharmaDivision of Allergy and Immunology, Children's National Health Systems, Washington, DC.
Amal H Assa'adDivision of Allergy & Immunology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Ruchi S GuptaCenter for Food Allergy and Asthma Research and Institute for Public Health and Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill; Advanced General Pediatrics and Primary Care, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Ill.
Northwestern University · USChildren's National · USRush University Medical Center · USCincinnati Children's Hospital Medical Center · USLurie Children's Hospital · USUniversity of Illinois Chicago · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
FORWARD Supplement Standardizing EHR Data CollectionR01AI130348 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ruchi S Gupta · 2017 to 2026
$10.9M
Institutional Career Development Core (Chapter 1)KL2TR002387 · NCATS · UNIVERSITY OF CHICAGO · PI ERIC C BEYER, Lisa L Barnes · 2017 to 2026
$7.6M
NCATS NIH HHS KL2 TR002387NCATS NIH HHS UL1 TR001422NIAID NIH HHS R01 AI130348
6 · The paper itself

Abstract

backgroundDespite major differences in health profiles and rates of health care utilization between African American and White children with food allergy (FA), the detailed phenotypic variables that can potentially impact these outcomes have not been thoroughly studied.

objectiveWe aimed to characterize phenotypic differences such as allergies to different foods and allergic comorbidities between African American and White children with FA enrolled in the Food Allergy Outcomes Related to White and African American Racial Differences study.

methodsOur active, prospective, multicenter cohort study is currently enrolling African American and White children aged 0 to 12 years diagnosed with FA and followed by allergy/immunology clinics at 4 urban tertiary centers in the United States. To evaluate associations between race and phenotypic variables, we used multivariable logistic regression, adjusting for important demographic and confounding factors, as well as potential household clustering.

resultsAs of May 2020, there were 239 African Americans and 425 Whites with complete intake information enrolled in the study. In comparison with Whites, we found that African Americans had significantly higher adjusted odds of allergy to finfish (odds ratio [OR]: 2.54, P < .01) and shellfish (OR: 3.10, P < .001). African Americans also had higher adjusted odds of asthma than Whites (asthma prevalence of 60.5% in African Americans and 27.2% in Whites; OR: 2.70, P < .001). In addition, shellfish allergy was associated with asthma, after controlling for race.

conclusionAmong a diverse cohort of children with physician-diagnosed FA, we observed that African American children had higher odds of allergy to shellfish and finfish, and higher rates of asthma. Interestingly, having asthma was independently associated with allergy to shellfish, after controlling for race.

Indexed as

Black or African AmericanFood HypersensitivityChildCohort StudiesHumansProspective StudiesShellfishUnited StatesAfrican AmericanAsthmaFood allergyFORWARDRace

Identifiers

PMID33359586
PMCPMC8277659
OpenAlexW3114073957

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.