Evidence map›Paper›PMID 33359476›Full record

ArticleJournal of the American Academy of Dermatology2021

Eruptions and related clinical course among 296 hospitalized adults with confirmed COVID-19.

Sergey Rekhtman, Rachel Tannenbaum, Andrew Strunk, Morgan Birabaharan, Shari Wright, Nicole Grbic, Ashna Joseph, Stephanie K Lin, Aaron C Zhang, Eric C Lee and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of the American Academy of Dermatology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Oral Manifestations of COVID-19 in Hospitalized Patients: A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  3. Pooled it
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  8. Review
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  11. Necrotic lesions on the face in a patient with COVID-19.Journal de medecine vasculaire · 2022
    Article
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  14. Review
  15. Ulcus vulvae acutum and SARS-CoV-2: an aetiological role?Journal of the European Academy of Dermatology and Venereology : JEADV · 2021
    Article
  16. Review
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  20. Defining the short-term and long-term skin manifestations of COVID-19: insights after more than three years of the pandemic.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Sergey RekhtmanDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, New York.
Rachel TannenbaumDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, New York.
Andrew StrunkDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, New York.
Morgan BirabaharanDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, New York.
Shari WrightDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, New York.
Nicole GrbicDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, New York.
Ashna JosephDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, New York.
Stephanie K LinDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, New York.
Aaron C ZhangDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, New York.
Eric C LeeDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, New York.
Erika RiveraDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, New York.
Michael QiuCenter for Research Informatics and Innovation, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
John ChelicoCenter for Research Informatics and Innovation, The Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York; Department of Medicine, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, New Hyde Park, New York.
Amit GargDepartment of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra Northwell, Hempstead, New York. Electronic address: amgarg@northwell.edu.
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell · USNorthwell Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLimited information exists on mucocutaneous disease and its relation to course of COVID-19.

objectiveTo estimate prevalence of mucocutaneous findings, characterize morphologic patterns, and describe relationship to course in hospitalized adults with COVID-19.

methodsProspective cohort study at 2 tertiary hospitals (Northwell Health) between May 11, 2020 and June 15, 2020.

resultsAmong 296 hospitalized adults with COVID-19, 35 (11.8%) had at least 1 disease-related eruption. Patterns included ulcer (13/35, 37.1%), purpura (9/35, 25.7%), necrosis (5/35, 14.3%), nonspecific erythema (4/35, 11.4%), morbilliform eruption (4/35, 11.4%), pernio-like lesions (4/35, 11.4%), and vesicles (1/35, 2.9%). Patterns also showed anatomic site specificity. A greater proportion of patients with mucocutaneous findings used mechanical ventilation (61% vs 30%), used vasopressors (77% vs 33%), initiated dialysis (31% vs 9%), had thrombosis (17% vs 11%), and had in-hospital mortality (34% vs 12%) compared with those without mucocutaneous findings. Patients with mucocutaneous disease were more likely to use mechanical ventilation (adjusted prevalence ratio, 1.98; 95% confidence interval, 1.37-2.86); P < .001). Differences for other outcomes were attenuated after covariate adjustment and did not reach statistical significance. LIMITATIONS: Skin biopsies were not performed.

conclusionsDistinct mucocutaneous patterns were identified in hospitalized adults with COVID-19. Mucocutaneous disease may be linked to more severe clinical course.

Indexed as

Acute Kidney InjuryAgedBlisterChilblainsCOVID-19ErythemaExanthemaFemaleHospitalizationHospital MortalityHumansMaleMiddle AgedMucous MembraneNecrosisProspective StudiesVasoconstrictor AgentsadultsCOVID-19eruptionhospitalizedmorbilliformmucocutaneousnecrosisNorthwellpurpurarashSarsCoV-2ulcer

Identifiers

PMID33359476
PMCPMC7837130
OpenAlexW3114109418

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.