ArticleNeuroImage2021
Co-activation patterns across multiple tasks reveal robust anti-correlated functional networks.
Article in NeuroImage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Convergent and divergent spatial topographies of individualized brain functional networks and their developmental origins.Psychoradiology · 2026Article
- Quantifying Similarity of Dynamic Brain Networks: Two Novel Indices for Structural Change and Temporal Evolution.Bioengineering (Basel, Switzerland) · 2025Article
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- st-DenseViT: A Weakly Supervised Spatiotemporal Vision Transformer for Dense Prediction of Dynamic Brain Networks.Human brain mapping · 2025Article
- Disentangling large-scale brain dynamics and their links to behavior during the emotional face matching task.Communications biology · 2025Article
- Functional Connectivity Patterns Following Mild Traumatic Brain Injury and the Association With Longitudinal Cognitive Function.Human brain mapping · 2025Article
- Repetitive transcranial magnetic stimulation enhanced by neuronavigation in the treatment of depressive disorder and schizophrenia.World journal of psychiatry · 2024Article
- Sex Differences in Hierarchical and Modular Organization of Functional Brain Networks: Insights from Hierarchical Entropy and Modularity Analysis.Entropy (Basel, Switzerland) · 2024Article
- Article
- Early altered directionality of resting brain network state transitions in the TgF344-AD rat model of Alzheimer's disease.Frontiers in human neuroscience · 2024Article
- Improved clinical outcome prediction in depression using neurodynamics in an emotional face-matching functional MRI task.Frontiers in psychiatry · 2024Article
- Recovery of inhibitory control prefrontal cortex function in inpatients with heroin use disorder: a 15-week longitudinal fMRI study.medRxiv : the preprint server for health sciences · 2023Article
- Individualized functional connectome identified generalizable biomarkers for psychiatric symptoms in transdiagnostic patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy.Brain : a journal of neurology · 2023Article
- Uncovering the biological basis of control energy: Structural and metabolic correlates of energy inefficiency in temporal lobe epilepsy.Science advances · 2022Article
- Edge-centric analysis of time-varying functional brain networks with applications in autism spectrum disorder.NeuroImage · 2022Article
- Spatiotemporal patterns of spontaneous brain activity: a mini-review.Neurophotonics · 2022Review
- [The measurements of the similarity of dynamic brain functional network].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2022Article
- Fast cortical surface reconstruction from MRI using deep learning.Brain informatics · 2022Article
- Understanding cognitive control in aging: A brain network perspective.Frontiers in aging neuroscience · 2022Review
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Authors and funding
15 authors.
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Abstract
Whether antagonistic brain states constitute a fundamental principle of human brain organization has been debated over the past decade. Some argue that intrinsically anti-correlated brain networks in resting-state functional connectivity are an artifact of preprocessing. Others argue that anti-correlations are biologically meaningful predictors of how the brain will respond to different stimuli. Here, we investigated the co-activation patterns across the whole brain in various tasks and test whether brain regions demonstrate anti-correlated activity similar to those observed at rest. We examined brain activity in 47 task contrasts from the Human Connectome Project (N = 680) and found robust antagonistic interactions between networks. Regions of the default network exhibited the highest degree of cortex-wide negative connectivity. The negative co-activation patterns across tasks showed good correspondence to that derived from resting-state data processed with global signal regression (GSR). Interestingly, GSR-processed resting-state data was a significantly better predictor of task-induced modulation than data processed without GSR. Finally, in a cohort of 25 patients with depression, we found that task-based anti-correlations between the dorsolateral prefrontal cortex (DLPFC) and subgenual anterior cingulate cortex were associated with clinical efficacy of transcranial magnetic stimulation therapy targeting the DLPFC. Overall, our findings indicate that anti-correlations are a biologically meaningful phenomenon and may reflect an important principle of functional brain organization.
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