ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2021
Differential Effects of Early Adversity and Posttraumatic Stress Disorder on Amygdala Reactivity: The Role of Developmental Timing.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The effects of childhood adversity: Two specific neural patterns.Neuroscience and biobehavioral reviews · 2025Pooled it
- Adverse Life Experiences and Brain Function: A Meta-Analysis of Functional Magnetic Resonance Imaging Findings.JAMA network open · 2023Pooled it
- Hormonal mechanisms of women's risk in the face of traumatic stress.Proceedings of the National Academy of Sciences of the United States of America · 2025Trial
- Associations of childhood maltreatment types and timing with oxidative stress in formerly out-of-home placed young adults.European journal of psychotraumatology · 2026Article
- Critical windows: timing of child maltreatment exposure and adult mental health.Child and adolescent psychiatry and mental health · 2026Article
- Glucose as fuel for HPA axis regulation: A narrative review on energy metabolism, stress reactivity, and early life adversity.Comprehensive psychoneuroendocrinology · 2026Review
- Emotional scars: limbic brain processing alterations in adults with childhood abuse across mental health disorders.Molecular psychiatry · 2026Article
- Sad emotion processing-related theta oscillation patterns link suicide attempt to childhood trauma in depression: evidence from MEG.Translational psychiatry · 2026Article
- Frequency of bullying modulates amygdala response during social exclusion in participants with non-suicidal self-injury.European child & adolescent psychiatry · 2026Article
- Corticolimbic structure-function coupling is sensitive to childhood adversity and buffers adversity-related symptoms during development.bioRxiv : the preprint server for biology · 2025Article
- Sex-Specific Effects of Early-Life Unpredictability on Hippocampal and Amygdala Responses to Novelty in Adolescents.Biological psychiatry global open science · 2025Article
- Differential effects of childhood maltreatment types and timing on psychopathology in formerly out-of-home placed young adults.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- The moderating effect of lifetime physical activity on brain alterations related to adverse childhood experiences.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Validation of an electronic self-administered version of the Dimensional Inventory of Stress and Trauma Across the Lifespan in a large sample of young adults.Psychological trauma : theory, research, practice and policy · 2025Article
- Person-centered analyses reveal that developmental adversity at moderate levels and neural threat/safety discrimination are associated with lower anxiety in early adulthood.Communications psychology · 2025Article
- Neural correlates of reduction in self-judgment after mindful self-compassion training: A pilot study with resting state fMRI.Journal of mood and anxiety disorders · 2025Article
- Childhood trauma is associated with perceived stress and hair cortisol levels characterized by the BDNF Val66Met genotype and sex.Frontiers in psychiatry · 2025Article
- The association between adverse childhood experiences and alterations in brain volume and cortical thickness in adults with alcohol use disorder.Addiction biology · 2024Article
- New insights into the effects of type and timing of childhood maltreatment on brain morphometry.Scientific reports · 2024Article
- Polygenic risk for epigenetic aging and adverse life experiences interact to predict growth in adolescent depression in a racially/ethnically diverse sample.Frontiers in psychiatry · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPosttraumatic stress disorder (PTSD) is associated with altered processing of threat-related stimuli. Neurobiological models implicate right amygdala hyperreactivity in these alterations, but this potential biomarker also has been observed in individuals exposed to adverse childhood experiences (ACEs) (i.e., abuse and neglect) without psychopathology. Separation of the differential contributions of PTSD and ACEs to amygdala reactivity might benefit from incorporating the developmental timing of the events.
methodsWe conducted comprehensive retrospective interviews assessing ACEs for each life year between the ages of 1 and 17 years in a sample of 60 women exposed to trauma (including 34 participants with PTSD and 26 healthy participants). Functional magnetic resonance imaging was used to extract amygdala reactivity to threatening versus neutral scenes. Amygdala reactivity was predicted from PTSD diagnosis, total ACE severity, and ACE severity by life year using random forest regression.
resultsPTSD and ACEs significantly predicted reactivity in the right amygdala (R
conclusionsThe opposing effects of PTSD and ACEs caution against simplistic etiological and diagnostic interpretations of amygdala function. The identification of potentially sensitive periods for the effects of ACEs on amygdala reactivity to threat may help to uncover interactions between traumatization and development of PTSD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.