Evidence map›Paper›PMID 33359073›Full record

ArticleNeuropharmacology2021

Treatment of acetylcholinesterase inhibitor-induced seizures with polytherapy targeting GABA and glutamate receptors.

Lucille Lumley, Jerome Niquet, Brenda Marrero-Rosado, Mark Schultz, Franco Rossetti, Marcio de Araujo Furtado, Claude Wasterlain

Open access · hybridAbstract read
In one paragraph

Article in Neuropharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  12. Article
  13. Cattle BileFrontiers in pharmacology · 2022
    Article
  14. Article
  15. Article
  16. Concise Synthesis of Both Enantiomers of Pilocarpine.Molecules (Basel, Switzerland) · 2021
    Article
  17. Article
  18. Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy.Frontiers in molecular neuroscience · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Lucille LumleyNeuroscience Department, US Army Medical Research Institute of Chemical Defense (USAMRICD), Aberdeen Proving Ground, MD, USA. Electronic address: Lucille.a.lange.civ@mail.mil.
Jerome NiquetDepartment of Neurology, David Geffen School of Medicine at UCLA, Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
Brenda Marrero-RosadoNeuroscience Department, US Army Medical Research Institute of Chemical Defense (USAMRICD), Aberdeen Proving Ground, MD, USA.
Mark SchultzNeuroscience Department, US Army Medical Research Institute of Chemical Defense (USAMRICD), Aberdeen Proving Ground, MD, USA.
Franco RossettiMilitary Psychiatry and Neuroscience Department, Walter Reed Army Institute of Research, Silver Spring, MD, USA.
Marcio de Araujo FurtadoUniformed Services University, Bethesda, MD, USA.
Claude WasterlainDepartment of Neurology, David Geffen School of Medicine at UCLA, Epilepsy Research Laboratory (151), Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA.
VA Greater Los Angeles Healthcare System · USUniformed Services University of the Health Sciences · USWalter Reed Army Institute of Research · US

Funding

Rational polytherapy in the treatment of cholinergic seizuresU01NS074926 · NINDS · BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE · PI WASTERLAIN, CLAUDE G · 2011 to 2015
$3.3M
The carboxylesterase knockout mouse as a model to evaluate the efficacy of delayed medical countermeasures against soman exposureR21NS103820 · NINDS · GENEVA FOUNDATION · PI LANGE, LUCILLE · 2017 to 2018
$329k
Treatment of Status Epilepticus: A Translational ProposalI01BX000273 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI WASTERLAIN, CLAUDE G · 2009 to 2017
–
BLRD VA I01 BX000273NINDS NIH HHS R21 NS103820NINDS NIH HHS U01 NS074926
6 · The paper itself

Abstract

The initiation and maintenance of cholinergic-induced status epilepticus (SE) are associated with decreased synaptic gamma-aminobutyric acid A receptors (GABA

Indexed as

AnimalsAnticonvulsantsCholinesterase InhibitorsDrug Delivery SystemsDrug Therapy, CombinationExcitatory Amino Acid AntagonistsFemaleGABA ModulatorsMaleMiceMice, KnockoutRatsRats, Sprague-DawleyReceptors, GABAReceptors, GlutamateSeizuresAnticonvulsantsCholinesterase InhibitorsExcitatory Amino Acid AntagonistsGABA ModulatorsReceptors, GABAReceptors, GlutamateKetamineOrganophosphorusPharmacoresistancePilocarpineSeizureSoman

Identifiers

PMID33359073
PMCPMC7944923
OpenAlexW3113445874

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.