Evidence map›Paper›PMID 33359014›Full record

ArticleThe Journal of infection2021

Incidence and disease burden of herpes zoster in the population aged ≥50 years in China: Data from an integrated health care network.

Xiaohui Sun, Zheng Wei, Hongbo Lin, Mark Jit, Zhenwei Li, Chuanxi Fu

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In one paragraph

Article in The Journal of infection, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 10 pooled it
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 10 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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  8. Corticosteroids for preventing postherpetic neuralgia.The Cochrane database of systematic reviews · 2023
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Xiaohui SunDepartment of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, No. 548, Binwen Rd, Hangzhou 310053, China.
Zheng WeiDepartment of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, No. 548, Binwen Rd, Hangzhou 310053, China.
Hongbo LinCenter for Disease Control and Prevention of Yinzhou District, Ningbo, Zhejiang 315100, China.
Mark JitThe National Institute for Health Research (NIHR) Health Protection Research Unit in Immunisation, London School of Hygiene & Tropical Medicine, London, UK.
Zhenwei LiDepartment of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, No. 548, Binwen Rd, Hangzhou 310053, China.
Chuanxi FuDepartment of Epidemiology, School of Public Health, Zhejiang Chinese Medical University, No. 548, Binwen Rd, Hangzhou 310053, China. Electronic address: fuchuanxi@zcmu.edu.cn.
Zhejiang Chinese Medical University · CNLondon School of Hygiene & Tropical Medicine · GBNingbo Center for Disease Control and Prevention · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHerpes zoster (HZ) mainly affects elderly and immunocompromised individuals and is characterized by a painful vesicular rash. Data on the epidemiology of HZ, particularly in unvaccinated individuals aged ≥50 years, are still limited in China. Thus, this study aimed to evaluate the epidemiological features, disease burden, and associated risk factors of HZ in the population aged ≥50 years in China.

methodsWe evaluated HZ patients who were aged ≥50 years between January 1, 2015 and December 31, 2017 in the electronic health record database of Yinzhou district. HZ and its complications were identified using ICD-10 codes. In addition, post-herpetic neuralgia (PHN) as a complication of HZ was defined as pain occurring or persisting 90 days after rash onset. The disease burden was estimated according to the duration of hospitalization, frequency of visits, pharmacological treatment cost, and examination cost. Cox proportional hazards regression was used to investigate the associated risk factors for HZ.

resultsThe overall incidence of HZ was 6.64 per 1000 person-years. Of the 4,313 initial episodes from 2015 to 2017, there were 99 recurrent cases. In total, 7.26% and 3.94% of the HZ patients had PHN and other complications, respectively. The average frequency of outpatient visits was significantly lower in patients with initial disease than that in patients with recurrence (3.6 vs. 6.7 per patient). The mean duration of hospital stay was longer in the recurrent episode than that in the initial episode (24.0 vs. 21.6 days). The inpatient and outpatient cost per new-onset HZ was approximately ¥8116.9 and ¥560.2 per patient, respectively. Age; female sex; suburban residency; and presence of immunocompromised disease, hypertension, or diabetes were significantly associated with the development of HZ.

conclusionThe incidence and recurrence rates of HZ showed different trends with increasing age. The presence of HZ-related complications increased the direct medical costs. Our findings help provide a basis for developing appropriate strategies for HZ prevention and control.

Indexed as

Herpes ZosterNeuralgia, PostherpeticAgedChinaCost of IllnessFemaleHerpesvirus 3, HumanHumansIncidenceDisease burdenHerpes zosterOlder adultsRisk factor

Identifiers

PMID33359014
OpenAlexW3117936081

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.