ArticleJACC. Clinical electrophysiology2021
Early Versus Delayed Lead Extraction in Patients With Infected Cardiovascular Implantable Electronic Devices.
Article in JACC. Clinical electrophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 54 citations in OpenAlex.
- Surgical complications of cardiac implantable electronic devices: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- 2023 European Society of Cardiology guidelines for the management of infective endocarditis : Statement of endorsement by the NVVC Full version.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Review
- Preventing complications in cardiac pacemaker therapy: a lifecycle-based risk management framework.Frontiers in cardiovascular medicine · 2026Review
- 2023 European Society of Cardiology guidelines for the management of infective endocarditis : Statement of endorsement by the NVVC Short version.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Review
- Temporal Trends in Utilization of Transvenous Lead Extractions Among Cardiac Implantable Electronic Device Infections.JACC. Asia · 2025Article
- Management of Gunshot Injury Involving Cardiac Implantable Electronic Device.JACC. Case reports · 2025Article
- Importance of Surgical Timing in Right-Side Cardiac Implantable Electronic Device Infective Endocarditis.JACC. Case reports · 2025Article
- Cardiovascular Implantable Electronic Device Infections: A Contemporary Review.Infectious disease clinics of North America · 2024Review
- Article
- Inflammatory biomarkers as predictors of systemic vs isolated pocket infection in patients undergoing transvenous lead extraction.Heart rhythm O2 · 2024Article
- Contemporary Management of Cardiac Implantable Electronic Device Infection: The American College of Cardiology COGNITO Survey.JACC. Advances · 2024Article
- Cardiac device infection: removing barriers to timely and adequate treatment.European heart journal · 2023Article
- Risk factors associated with higher mortality in patients with cardiac implantable electronic device infection.Journal of cardiovascular electrophysiology · 2023Article
- Clinical and financial outcomes of hospitalizations for cardiac device infection during the COVID-19 pandemic in the US.PloS one · 2023Article
- Treatment and Prevention of Cardiovascular Implantable Electronic Device (CIED) Infections.CJC open · 2022Review
- Implantable loop recorder as a strategy following cardiovascular implantable electronic device extraction without reimplantation.Pacing and clinical electrophysiology : PACE · 2022Article
- Intelligent Detection and Diagnosis of Power Failure Relying on BP Neural Network Algorithm.Computational intelligence and neuroscience · 2022Article
- Article
- Social Media in Physician Education.Cureus · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectivesThis study sought to assess the impact of early versus delayed lead extraction in patients with an infected cardiovascular implantable electronic device (CIED).
backgroundCIED infections are associated with poor outcomes. Prior studies have demonstrated improved survival with CIED extraction compared with antibiotic therapy alone. The impact of timing of CIED extraction has not been well characterized.
methodsAll infected CIED extraction cases at our medical center from 2006 to 2019 were reviewed. Patients were divided into 2 groups based on the presence of bacteremia or isolated pocket infection. We assessed the in-hospital morbidity and 1-year mortality for early versus delayed lead extraction, using hospitalization day 7 as cutoff.
resultsOf 233 patients who underwent CIED extraction, 127 patients had bacteremia and 106 patients had pocket infection. Delayed extraction (15.2 days) in bacteremic patients was associated with septic shock (odds ratio [OR]: 5.39; 95% confidence interval [CI]: 1.23 to 23.67; p = 0.026), acute kidney injury (OR: 5.61; 95% CI: 2.15 to 14.63; p < 0.001), respiratory failure (OR: 5.52; 95% CI: 1.25 to 24.41; p = 0.024), and decompensated heart failure (OR: 3.32; 95% CI: 1.10 to 10.05; p = 0.033). Locally infected patients with delayed extraction (10.7 days) were associated with acute kidney injury (OR: 3.45; 95% CI: 1.11 to 10.77; p = 0.033) and respiratory failure (OR: 10.29; 95% CI: 1.26 to 83.93; p = 0.030). Delayed CIED extraction in both groups was associated with increased 1-year mortality.
conclusionsDelayed infected CIED extraction is associated with worse outcomes. This underscores the importance of early detection and a strategy for prompt management including lead extraction.
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