Evidence map›Paper›PMID 33358629›Full record

ReviewCurrent opinion in neurobiology2021

Multiregional communication and the channel modulation hypothesis.

Bijan Pesaran, Maureen Hagan, Shaoyu Qiao, Ryan Shewcraft

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bijan PesaranCenter for Neural Science, New York University, New York, NY 10003, USA. Electronic address: bijan@nyu.edu.
Maureen HaganBiomedicine Discovery Institute, Department of Physiology, Monash University, Clayton, VIC 3800, Australia.
Shaoyu QiaoCenter for Neural Science, New York University, New York, NY 10003, USA.
Ryan ShewcraftCenter for Neural Science, New York University, New York, NY 10003, USA.

Funding

Optimizing flexible, active electrode arrays for chronic, large-scale recording and stimulation on the scale of 100,000 electrodesU01NS099697 · NINDS · DUKE UNIVERSITY · PI BRAUN, PAUL, PESARAN, BIJAN · 2016 to 2018
$3.5M
Predictive models of brain dynamics during decision making and their validation using distributed optogenetic stimulationR01NS104923 · NINDS · NEW YORK UNIVERSITY · PI KIANI, ROOZBEH · 2017 to 2021
$3.5M
A microscope optimized for brain-scale 2-photon imagingU01NS103518 · NINDS · NEW YORK UNIVERSITY · PI PESARAN, BIJAN · 2017 to 2019
$2.9M
Multiple spatial representations during visually-guided behaviorR01EY024067 · NEI · NEW YORK UNIVERSITY · PI PESARAN, BIJAN · 2014 to 2018
$1.9M
NEI NIH HHS R01 EY024067NINDS NIH HHS R01 NS104923NINDS NIH HHS U01 NS099697NINDS NIH HHS U01 NS103518
6 · The paper itself

Abstract

Multiregional communication is important to understanding the brain mechanisms supporting complex behaviors. Work in animals and human subjects shows that multiregional communication plays significant roles in cognitive function and is associated with neurological and neuropsychiatric disorders of brain function. Recent experimental advances enable empirical tests of the mechanisms of multiregional communication. Recent mechanistic insights into brain network function also suggest new therapies to treat disordered brain networks. Here, we discuss how to use the concept of communication channel modulation can help define and constrain what we mean by multiregional communication. We discuss behavioral and neurophysiological evidence for multiregional channels modulation. We then consider the role of causal manipulations and their implications for developing novel therapies based on multiregional communication.

Indexed as

BrainCommunicationAnimalsHumans

Identifiers

PMID33358629
PMCPMC8058233

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.