Evidence map›Paper›PMID 33358395›Full record

ArticleAnnals of emergency medicine2021

Evaluating Sex Disparities in the Emergency Department Management of Patients With Suspected Acute Coronary Syndrome.

Salena M Preciado, Adam L Sharp, Benjamin C Sun, Aileen Baecker, Yi-Lin Wu, Ming-Sum Lee, Ernest Shen, Maros Ferencik, Shaw Natsui, Aniket A Kawatkar and 2 more

Open access · bronzeAbstract readComparative StudyMulticenter Study
In one paragraph

Article in Annals of emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. Observational
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Observational
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Salena M PreciadoDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA.
Adam L SharpDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA.
Benjamin C SunDepartment of Emergency Medicine, University of Pennsylvania, Leonard Davis Institute, Philadelphia, PA.
Aileen BaeckerDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA.
Yi-Lin WuDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA.
Ming-Sum LeeDivision of Cardiology, Kaiser Permanente Southern California, Los Angeles Medical Center, Los Angeles, CA.
Ernest ShenDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA.
Maros FerencikKnight Cardiovascular Institute, Oregon Health & Science University, Portland, OR.
Shaw NatsuiNew York City Health + Hospitals, New York, NY.
Aniket A KawatkarDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA.
Stacy J ParkDepartment of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA.
Rita F RedbergDivision of Cardiology, University of California-San Francisco, San Francisco, CA. Electronic address: rita.redberg@ucsf.edu.
Kaiser Permanente · USLos Angeles Medical Center · USNew York City Health and Hospitals Corporation · USOregon Health & Science University · USUniversity of California, San Francisco · USUniversity of Pennsylvania · US

Funding

Comparative Effectiveness of Early Diagnostic and Disposition Strategies for Suspected Acute Coronary SyndromeR01HL134647 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SUN, BENJAMIN C · 2017 to 2020
$3.1M
NHLBI NIH HHS R01 HL134647
6 · The paper itself

Abstract

STUDY

objectiveWe compare clinical management and outcomes of emergency department (ED) encounters by sex after implementation of a clinical care pathway in 15 community EDs that standardized recommendations based on patient risk, using the History, ECG, Age, Risk Factors, and Troponin (HEART) score.

methodsThis was a retrospective analysis of adult ED encounters evaluated for suspected acute coronary syndrome with a documented HEART score from May 20, 2016, to December 1, 2017. The primary outcomes were hospitalization or 30-day stress testing. Secondary outcomes included 30-day acute myocardial infarction or all-cause death (major adverse cardiac event). A generalized estimating equation regression model was used to compare the odds of hospitalization or stress testing by sex; we report HEART scores (0 to 10) stratified by sex and describing major adverse cardiac events.

resultsA total of 34,715 adult ED encounters met the inclusion criteria (56.0% women). A higher proportion of women were classified as low risk (60.5% versus 52.4%; odds ratio [OR] 1.39; 95% confidence interval [CI] 1.33 to 1.45). Women were hospitalized or received stress testing less frequently than men for low HEART scores (18.8% versus 22.8%; OR 0.79; 95% CI 0.73 to 0.84) and intermediate ones (46.7% versus 49.7%; OR 0.88; 95% CI 0.83 to 0.95), but similarly for high-risk ones (74.1% versus 74.4%; OR 0.99; 95% CI 0.77 to 1.28). Women had 18% lower odds of hospitalization or noninvasive cardiac testing (OR 0.82; 95% CI 0.78 to 0.86), even after adjusting for HEART score and comorbidities. Men had higher risks of major adverse cardiac events than women for all HEART score categories but the risk for men was significantly higher among low-risk HEART scores (0.4% versus 0.1%).

conclusionWomen with low-risk HEART scores are hospitalized or stress tested less than men, which is likely appropriate, and women have better outcomes than men. Use of the HEART score has the potential to reduce sex disparities in acute coronary syndrome care.

Indexed as

Critical PathwaysAcute Coronary SyndromeAgedEmergency Service, HospitalFemaleHumansMaleMiddle AgedRetrospective StudiesRisk AssessmentSex Factors

Identifiers

PMID33358395
PMCPMC8005458
OpenAlexW3114199754

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.