Does opioid substitution treatment have a protective effect on the clinical manifestations of COVID-19? Comment on Br J Anaesth 2020; 125: e382-3.

Marie Eagleton, Siobhan Stokes, Fiona Fenton, Eamon Keenan

Abstract readLetterComment

In one paragraph

Article in British journal of anaesthesia, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Opioids and opioid receptors; understanding pharmacological mechanisms as a key to therapeutic advances and mitigation of the misuse crisis.BJA open · 2023
Review
A cross-section observational study on the seroprevalence of antibodies to COVID-19 in patients receiving opiate agonist treatment.Irish journal of medical science · 2022
Observational
Lipid rafts as viral entry routes and immune platforms: A double-edged sword in SARS-CoV-2 infection?Biochimica et biophysica acta. Molecular and cell biology of lipids · 2022
Review
Therapeutic potential of long-acting opioids and opioid antagonists for SARS-CoV-2 infection.British journal of anaesthesia · 2021
Article
Anaesthesia-related drugs and SARS-CoV-2 infection.British journal of anaesthesia · 2021
Article

4 · The record

Corrections and comments

Comment on
Opioids and the COVID-19 pandemic: does chronic opioid use or misuse increase clinical vulnerability?2020

5 · Who and what money

Authors and funding

4 authors.

Marie EagletonHSE National Drug Treatment Centre, Dublin, Ireland. Electronic address: meagleton@dtcb.ie.

Siobhan StokesHSE National Drug Treatment Centre, Dublin, Ireland.

Fiona FentonHSE National Drug Treatment Centre, Dublin, Ireland.

Eamon KeenanAddiction Services National Social Inclusion Office, Health Service Executive, Dublin, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19PandemicsAnalgesics, OpioidHumansOpiate Substitution TreatmentSARS-CoV-2Analgesics, OpioidCOVID-19immunomodulationinflammationopioid substitution treatmentopioid use disorder

Identifiers

PMID33358041

DOI10.1016/j.bja.2020.11.027

PMCPMC7699021

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.