ArticlePoultry science2021
Propionate inhibits fat deposition via affecting feed intake and modulating gut microbiota in broilers.
Article in Poultry science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 39 citations in OpenAlex.
- Probiotics in Autoimmune Disease: Strain-specific Mechanisms and Therapeutic Perspectives.Clinical reviews in allergy & immunology · 2026Review
- Structurally distinct yeast-derived β-glucans modulate intestinal morphology and microbial metabolism in broiler chickens differentially.Poultry science · 2026Article
- Nutritional enrichment of eggs through essential oil-supplemented laying hen diets and associations with intestinal microbiota.Food science of animal resources · 2026Article
- The gut-liver axis in animal diseases: roles, mechanisms, and veterinary clinical applications.Frontiers in veterinary science · 2026Review
- Succinic acid-driven gut-fat axis orchestrates abdominal fat deposition in chickens via adipocyte-macrophage crosstalk.Journal of animal science and biotechnology · 2025Article
- Microencapsulated Propionate and Butyrate Improved Energy Balance and Gut Microbiota Composition in Diet-Induced Obese Rats.Nutrients · 2025Article
- Synergistic treatment of sodium propionate and Sishen Pill for diarrhea mice with kidney-yang deficiency syndrome.Frontiers in cellular and infection microbiology · 2025Article
- Role of Metabolomics and Metagenomics in the Replacement of the High-Concentrate Diet with a High-Fiber Diet for Growing Yushan Pigs.Animals : an open access journal from MDPI · 2024Article
- Dietary Factors Impact Developmental Trajectories in Young Autistic Children.Journal of autism and developmental disorders · 2024Article
- Prebiotic galactooligosaccharide feed modifies the chicken gut microbiota to efficiently clearmSystems · 2024Article
- Effect of High Dietary Iron on Fat Deposition and Gut Microbiota in Chickens.Animals : an open access journal from MDPI · 2024Article
- Article
- Effects of sex on fat deposition through gut microbiota and short-chain fatty acids in weaned pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2024Article
- Multiomics analysis reveals that microbiota regulate fat and muscle synthesis in chickens.Poultry science · 2024Article
- Pre-hatch thermal manipulation of embryos and post-hatch baicalein supplementation mitigated heat stress in broiler chickens.Journal of animal science and biotechnology · 2024Article
- Lipid complexation reduces rice starch digestibility and boosts short-chain fatty acid production via gut microbiota.NPJ science of food · 2023Article
- Effects of dietary supplementation of Anoectochilus roxburghii extract (ARE) on growth performance, abdominal fat deposition, meat quality, and gut microbiota in broilers.Poultry science · 2023Article
- The effects of plant extracts on lipid metabolism of chickens - A review.Animal bioscience · 2023Article
- Dietary folic acid addition reduces abdominal fat deposition mediated by alterations in gut microbiota and SCFA production in broilers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Article
- Preventing bacterial disease in poultry in the post-antibiotic era: a case for innate immunity modulation as an alternative to antibiotic use.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As one of the 3 main short-chain fatty acids, the role of propionate in chicken fat metabolism is largely unknown. In this study, we demonstrated that dietary supplementation of coated sodium propionate (SP) moderately inhibits fat deposition in broiler chickens, as evidenced by the decreased adipocyte mean area (P < 0.01), the lowered triglyceride content in abdominal fat tissue (P < 0.01), and the reduced transcription of several lipogenic genes in liver and abdominal fat tissues (P < 0.05). Surprisingly, the propionate content was not significantly elevated either in serum or in the cecal chyme by SP administration (P > 0.05). However, SP application significantly decreased the average daily feed intake of broilers (P < 0.05). In addition, the composition of the cecal microbial communities was altered, with the ratio of Firmicutes to Bacteroidetes decreasing in particular (P < 0.05). At the genus level, SP application increased the richness of Alistipes, Lactobacillus, and Bifidobacterium, while reduced the abundance of Lachnospiraceae and Helicobacter significantly (P < 0.05). Moreover, in vitro experiments indicated that, although physiological concentrations of propionate (0.01 to 0.1 mmol) upregulated or downregulated the transcription of some fat synthesis-associated genes (P < 0.05), they did not significantly affect the triglyceride accumulation in hepatocytes and adipocytes (P > 0.05). These results suggest that feed supplementation with SP inhibits fat deposition in broilers by reducing feed and caloric intake, but not via direct regulation on hepatic fat synthesis or adipocytic fat deposition. Alteration in the relative populations of the gut microflora suggests that SP may have gut health implications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.