ArticlePoultry science2021
Heat stress alters muscle protein and amino acid metabolism and accelerates liver gluconeogenesis for energy supply in broilers.
Article in Poultry science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- Global trends and research frontiers on heat stress in poultry from 2000 to 2021: A bibliometric analysis.Frontiers in physiology · 2023Pooled it
- Gut microbiota contributes to heat tolerance in chickens through metabolic remodeling and suppression of thermogenesis.Poultry science · 2026Article
- A Review on Heat Stress in Broiler Chickens: Mechanisms, Effects and Mitigation Strategies.Veterinary medicine and science · 2026Review
- Shotgun proteomic analysis of quail liver under feed deprivation and low-energy diet conditions.Veterinary and animal science · 2026Article
- Effects of probiotic and butyrate-based feed additives on growth performance, carcass yield and gut health of broiler chickens.Veterinary and animal science · 2026Article
- Mechanism of Silybin in Alleviating Liver Damage Induced by Heat Stress of Peking Ducks.Animals : an open access journal from MDPI · 2026Article
- Amino Acid Composition of Meat from Smena 9 Broiler Chickens During Ontogeny Under a High Stocking Density and Dietary Adaptogens Complex.Animals : an open access journal from MDPI · 2026Article
- Impacts of Enrichment Type (Hut vs. Platform) on Chronic Stress and Anxiety in Six Fast- and Slow-Growing Broiler Strains.Animals : an open access journal from MDPI · 2026Article
- Sheng Mai San Regulating the Oxidative Stress and Mitochondrial Damage to Alleviate Liver Injury in Heat Stress Rats.Animals : an open access journal from MDPI · 2026Article
- Using Spirulina (Limnospira platensis) as an alternative feedstuff for poultry: Effects on ammonia and greenhouse gas emissions from excreta during storage.Poultry science · 2026Article
- Effects of Low-Protein Diets on Growth Performance, Intestinal Morphology, Apparent Ileal Amino Acid Digestibility and Jejunal Amino Acid Transporter Gene Expression in Heat-Stressed Growing Male Pekin Ducks.Animals : an open access journal from MDPI · 2026Article
- Nutritional and managerial interventions on growth performance, nutrient transport-related genes and behavioral responses in heats stressed broiler chickens.Veterinary and animal science · 2026Article
- Genomic signatures of environmental adaptation in Danzhou chickens.BMC genomics · 2026Article
- Respiratory efficiency and thermoregulatory responses of L-citrulline-supplemented broiler chickens under acute and chronic stress conditions.Frontiers in physiology · 2026Article
- Chronic heat stress compromises egg production and quality parameters through changes in blood biochemistry and uterine gene expression in laying hens raised under cage-free environment.Frontiers in physiology · 2026Article
- Energy metabolic dysregulation in heat stroke: from mitochondrial dysfunction to multi-organ failure mechanisms and targeted intervention.Frontiers in pharmacology · 2026Review
- Effects of Supplementing Rumen-Protected Lysine and Methionine on Apparent Digestibility, Rumen Fermentation Parameters, and Microbial Profiles in Lactating Dairy Cows Under Different Environmental Conditions.Animals : an open access journal from MDPI · 2025Article
- Role of DietaryAnimals : an open access journal from MDPI · 2025Article
- Molecular Pathogenesis of Avian Splenic Injury Under Thermal Challenge: Integrated Mitigation Strategies for Poultry Heat Stress.Current issues in molecular biology · 2025Review
- Impact of stocking densities on growth, organ index, serum biochemistry, gut morphology and microbiota of young ducks in a rice-duck-crayfish coculture system.Animal bioscience · 2025Article
9 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress impairs growth performance and alters body protein and amino acid metabolism. This study was investigated to explore how body protein and amino acid metabolism changed under heat stress (HS) and the stress adaptation mechanism. A total of 144 broilers (28 d old) were divided into 3 treatment groups for 1 wk: HS group (32°C), normal control group (22°C), and pair-feeding group (22°C). We found that HS elevated the feed-to-gain ratio, reduced the ADFI and ADG, decreased breast muscle mass and plasma levels of several amino acids (glycine, lysine, threonine, and tyrosine), and increased serum glutamic oxaloacetic transaminase (GOT) activity and corticosterone (CORT) level and liver GOT and glutamic pyruvic transaminase activities. Heat stress elevated muscle atrophy F-box mRNA expression and reduced mRNA expression of the 70-kD ribosomal protein S6 kinase in the breast muscle of broilers. Broilers in the HS group exhibited striking increases of mRNA expressions of solute carrier family 1 member 1, family 3 member 1, family 7 member 1, and family 7 member-like in the liver and liver gluconeogenesis genes (PCKc, PCKm, PC, and FBP1) in comparison with the other 2 groups. In conclusion, HS increased the circulating CORT level and subsequently caused muscle protein breakdown to provide amino acid substrates to liver gluconeogenesis responsible for energy supply.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.