Evidence map›Paper›PMID 33357637›Full record

SynthesisIndian heart journal

A systematic review of ECG findings in patients with COVID-19.

Esmaeil Mehraeen, Seyed Ahmad Seyed Alinaghi, Ali Nowroozi, Omid Dadras, Sanam Alilou, Parnian Shobeiri, Farzane Behnezhad, Amirali Karimi

Open access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Indian heart journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 6 pooled it
1.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 6 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Are Pre-Hospitalization ECG Abnormalities Associated With Increased Mortality in COVID-19 Patients? A Quantitative Systematic Literature Review.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Esmaeil MehraeenDepartment of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal, Iran. Electronic address: es.mehraeen@gmail.com.
Seyed Ahmad Seyed AlinaghiIranian Research Center for HIV/AIDS, Iranian Institute for Reduction of High Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: s_a_alinaghi@yahoo.com.
Ali NowrooziSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: nowrooziali77@gmail.com.
Omid DadrasDepartment of Health Informatics, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Electronic address: omiddadras@yahoo.com.
Sanam AlilouSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: Sanamalilouu@gmail.com.
Parnian ShobeiriSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: Parnian.shobeiri@gmail.com.
Farzane BehnezhadDepartment of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: farzan1898@gmail.com.
Amirali KarimiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: aa-karimi@student.tums.ac.ir.
Iran University of Medical Sciences · IRTehran University of Medical Sciences · IRIranian Institute for Health Sciences Research · IRKyoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSince the epidemic of COVID-19 attracted the attention, reports were surrounding electrocardiographic changes in the infected individuals. We aimed at pinpointing different observed ECG findings and discussing their clinical significance.

methodsWe conducted a systematic search in PubMed, Embase, and Scopus databases. We included eligible original papers, reports, letters to the editors, and case reports published from December 2019 to May 10, 2020.

resultsThe team identified 20 articles related to this topic. We divided them into articles discussing drug-induced and non-drug-induced changes. Studies reported an increased risk of QTc interval prolongations influenced by different therapies based on chloroquine, hydroxychloroquine, and azithromycin. Although these medications increased risks of severe QTc prolongations, they induced no arrhythmia-related deaths. In the non-drug-induced group, ST-T abnormalities, notably ST elevation, accounted for the most observed ECG finding in the patients with COVID-19, but their relation with myocardial injuries was under dispute.

conclusionThis systematic review suggests that identifying ECG patterns that might be related to COVID-19 is vital. Provided that physicians do not recognize these patterns, they might erroneously risk the lives of their patients. Furthermore, important drug-induced ECG changes provide awareness to the health-care workers on the risks of possible therapies.

Indexed as

ElectrocardiographyArrhythmias, CardiacComorbidityCOVID-19HumansPandemicsSARS-CoV-2COVID-19ElectrocardiographySARS-CoV-2

Identifiers

PMID33357637
PMCPMC7661958
OpenAlexW3103205491

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.