ArticleCurrent biology : CB2021
An Epigenetic Priming Mechanism Mediated by Nutrient Sensing Regulates Transcriptional Output during C. elegans Development.
Article in Current biology : CB, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation in C. elegans.Nucleic acids research · 2026Article
- A molecular timer couples organism-wide temporal identity to developmental checkpoints.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- A developmental timer coordinates organism-wide microRNA transcription.bioRxiv : the preprint server for biology · 2026Article
- The Binding Landscape of an Essential Nuclear Hormone Receptor inbioRxiv : the preprint server for biology · 2025Article
- A scheduler for rhythmic gene expression.Molecular systems biology · 2025Article
- HLH-30/TFEB is necessary for chromatin reorganization and maintenance of cell quiescence during starvation inbioRxiv : the preprint server for biology · 2025Article
- A scheduler for rhythmic gene expression.bioRxiv : the preprint server for biology · 2025Article
- FLYWCH transcription factors act in a LIN-42/Period autoregulatory loop during gonad migration inbioRxiv : the preprint server for biology · 2025Article
- The NHR-23-regulated putative protease inhibitorbioRxiv : the preprint server for biology · 2024Article
- The Caenorhabditis elegans cuticle and precuticle: a model for studying dynamic apical extracellular matrices in vivo.Genetics · 2024Review
- Essential function of transmembrane transcription factor MYRF in promoting transcription of miRNAeLife · 2024Article
- Accelerated hermaphrodite maturation on male pheromones suggests a general principle of coordination between larval behavior and development.Development (Cambridge, England) · 2024Article
- Recent advances in understanding microRNA function and regulation in C. elegans.Seminars in cell & developmental biology · 2024Review
- A circadian-like gene network programs the timing and dosage of heterochronic miRNA transcription during C. elegans development.Developmental cell · 2023Article
- Transcriptional and spatiotemporal regulation of the dauer program.Transcription · 2023Review
- Article
- NHR-23 activity is necessary for C. elegans developmental progression and apical extracellular matrix structure and function.Development (Cambridge, England) · 2023Article
- C. elegans molting requires rhythmic accumulation of the Grainyhead/LSF transcription factor GRH-1.The EMBO journal · 2023Article
- Coupling of growth rate and developmental tempo reduces body size heterogeneity in C. elegans.Nature communications · 2022Article
- Deviations from temporal scaling support a stage-specific regulation for C. elegans postembryonic development.BMC biology · 2022Article
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7 authors at 3 institutions in 2 countries.
Funding
Abstract
Although precise tuning of gene expression levels is critical for most developmental pathways, the mechanisms by which the transcriptional output of dosage-sensitive molecules is established or modulated by the environment remain poorly understood. Here, we provide a mechanistic framework for how the conserved transcription factor BLMP-1/Blimp1 operates as a pioneer factor to decompact chromatin near its target loci during embryogenesis (hours prior to major transcriptional activation) and, by doing so, regulates both the duration and amplitude of subsequent target gene transcription during post-embryonic development. This priming mechanism is genetically separable from the mechanisms that establish the timing of transcriptional induction and functions to canalize aspects of cell-fate specification, animal size regulation, and molting. A key feature of the BLMP-1-dependent transcriptional priming mechanism is that chromatin decompaction is initially established during embryogenesis and maintained throughout larval development by nutrient sensing. This anticipatory mechanism integrates transcriptional output with environmental conditions and is essential for resuming normal temporal patterning after animals exit nutrient-mediated developmental arrests.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.